Near-infrared-IIb Emitting Single-atom Catalyst for Imaging-guided Therapy of Blood-brain Barrier Breakdown After Traumatic Brain Injury

Overview

Journal Nat Commun

Specialty Biology

Date 2023 Jan 13

PMID 36639379

Authors

Biao Huang

Tao Tang

Shi-Hui Chen

Hao Li

Zhi-Jun Sun

Zhi-Lin Zhang

Mingxi Zhang

Ran Cui

Affiliations

Soon will be listed here.

Abstract

The blood-brain barrier breakdown, as a prominent feature after traumatic brain injury, always triggers a cascade of biochemical events like inflammatory response and free radical-mediated oxidative damage, leading to neurological dysfunction. The dynamic monitoring the status of blood-brain barrier will provide potent guidance for adopting appropriate clinical intervention. Here, we engineer a near-infrared-IIb AgTe quantum dot-based Mn single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown of mice after traumatic brain injury. The dynamic change of blood-brain barrier, including the transient cerebral hypoperfusion and cerebrovascular damage, could be resolved with high spatiotemporal resolution (150 ms and ~ 9.6 µm). Notably, the isolated single Mn atoms on the surface of AgTe exhibited excellent catalytic activity for scavenging reactive oxygen species to alleviate neuroinflammation in brains. The timely injection of Mn single-atom catalyst guided by imaging significantly promoted the reconstruction of blood-brain barrier and recovery of neurological function after traumatic brain injury.

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