Restraint Stress Exacerbates Apoptosis in a 6-OHDA Animal Model of Parkinson Disease

Overview

Journal Neurotox Res

Publisher Springer

Specialty Neurology

Date 2023 Jan 12

PMID 36633788

Authors

Sara El Idrissi

Nada Fath

Hind Ibork

Khalid Taghzouti

Meryem Alamy

Oualid Abboussi

Affiliations

Soon will be listed here.

Abstract

Activation of the apoptotic pathway has been associated with promoting neuronal cell death in the pathophysiology of Parkinson disease (PD). Nonetheless, the mechanisms by which it may occur remain unclear. It has been suggested that stress-induced oxidation and potential apoptosis may play a major role in the progression of PD. Thus, in this study, we aimed to investigate the effect of subchronic restraint stress on striatal dopaminergic activity, iron, p53, caspase-3, and plasmatic acetylcholinesterase (AChE) levels in male Wistar rat model of PD induced by administration of 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle (MFB). The obtained results showed that restraint stress exacerbates motor coordination deficits and anxiety in animals treated with 6-OHDA in comparison to animals receiving saline, and it had no effect on object recognition memory. On another hand, 6-OHDA decreased dopamine (DA) levels, increased iron accumulation, and induced overexpression of the pro-apoptotic factors caspase-3, p53, and AChE. More interestingly, post-lesion restraint stress exacerbated the expression of caspase-3 and AChE without affecting p53 expression. These findings suggest that subchronic stress may accentuate apoptosis and may contribute to DA neuronal loss in the striatal regions and possibly exacerbate the progression of PD.

Citing Articles

Parkinson's disease models and death signaling: what do we know until now?.

Pedrao L, Medeiros P, Leandro E, Falquetto B Front Neuroanat. 2024; 18:1419108.

PMID: 39533977 PMC: 11555652. DOI: 10.3389/fnana.2024.1419108.

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