A Comprehensive Review of Genomic Perspectives of Canine Diseases As a Model to Study Human Disorders

Overview

Journal Can J Vet Res

Specialty Veterinary Medicine

Date 2023 Jan 6

PMID 36606040

Authors

Bhawanpreet Kaur

Jaswinder Kaur

Neeraj Kashyap

Jaspreet Singh Arora

Chandra Sekhar Mukhopadhyay

Affiliations

Soon will be listed here.

Abstract

The domestic dog has been given considerable attention as a system for investigating the genetics of human diseases. Population diversity and breed structure are unique features that make dogs particularly amenable to genetic studies. Dogs show distinguished features of breed-specific homogeneity, which is associated with striking interbreed heterogeneity. This review discusses the significance of studying the genetic maps, genome-wide association studies (GWAS), and usefulness of this species as an animal model. Most canine genetic disorders are similar to those of humans, including inherited, psychiatric, and genetic disorders. In addition to revealing new candidate genes, canine models allow access to experimental resources, such as cells, tissues, and even live animals, for research and intervention purposes.

Citing Articles

The beauty of the beast: Suggestions to curb the excesses of dog breeding and restore animal welfare - Invited review.

Diederich C Vet Med (Praha). 2025; 69(11):369-380.

PMID: 39810823 PMC: 11728315. DOI: 10.17221/62/2024-VETMED.

The markers of the predictive DNA test for canine hip dysplasia may have a stronger relationship with elbow dysplasia.

Ardicli S, Yigitgor P, Babayev H, Ozen D, Bozkurt B, Senturk N Heliyon. 2024; 10(18):e37716.

PMID: 39315210 PMC: 11417230. DOI: 10.1016/j.heliyon.2024.e37716.

Large-scale genomic analysis of the domestic dog informs biological discovery.

Buckley R, Ostrander E Genome Res. 2024; 34(6):811-821.

PMID: 38955465 PMC: 11293549. DOI: 10.1101/gr.278569.123.

Targeted Suicide Gene Therapy with Retroviral Replicating Vectors for Experimental Canine Cancers.

Sonoda-Fukuda E, Takeuchi Y, Ogawa N, Noguchi S, Takarada T, Kasahara N Int J Mol Sci. 2024; 25(5).

PMID: 38473904 PMC: 10932112. DOI: 10.3390/ijms25052657.

Missense Variant in a Lagotto Romagnolo Dog with Autosomal Recessively Inherited Limb-Girdle Muscular Dystrophy.

Brunetti B, Bacci B, Abbate J, Tura G, Paciello O, Vaccaro E Genes (Basel). 2023; 14(8).

PMID: 37628692 PMC: 10454570. DOI: 10.3390/genes14081641.

References

Bradbury A, Bagel J, Jiang X, Swain G, Prociuk M, Fitzgerald C . Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe's disease). J Neurosci Res. 2016; 94(11):1007-17. PMC: 5027978. DOI: 10.1002/jnr.23838. View

Khanna C, Lindblad-Toh K, Vail D, London C, Bergman P, Barber L . The dog as a cancer model. Nat Biotechnol. 2006; 24(9):1065-6. DOI: 10.1038/nbt0906-1065b. View

Menon K, Tieu P, Neufeld E . Architecture of the canine IDUA gene and mutation underlying canine mucopolysaccharidosis I. Genomics. 1992; 14(3):763-8. DOI: 10.1016/s0888-7543(05)80182-x. View

Sutter N, Eberle M, Parker H, Pullar B, Kirkness E, Kruglyak L . Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res. 2004; 14(12):2388-96. PMC: 534662. DOI: 10.1101/gr.3147604. View

Forman O, Hitti R, Pettitt L, Jenkins C, OBrien D, Shelton G . An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed. G3 (Bethesda). 2016; 6(9):2687-92. PMC: 5015927. DOI: 10.1534/g3.116.027896. View

Correard S, Plassais J, Lagoutte L, Botherel N, Thibaud J, Hedan B . Canine neuropathies: powerful spontaneous models for human hereditary sensory neuropathies. Hum Genet. 2019; 138(5):455-466. DOI: 10.1007/s00439-019-02003-x. View

Beltran W, Cideciyan A, Lewin A, Iwabe S, Khanna H, Sumaroka A . Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A. 2012; 109(6):2132-7. PMC: 3277562. DOI: 10.1073/pnas.1118847109. View

Bradbury A, Rafi M, Bagel J, Brisson B, Marshall M, Salvador J . AAVrh10 Gene Therapy Ameliorates Central and Peripheral Nervous System Disease in Canine Globoid Cell Leukodystrophy (Krabbe Disease). Hum Gene Ther. 2018; 29(7):785-801. PMC: 6066194. DOI: 10.1089/hum.2017.151. View

Lairmore M, Khanna C . Naturally occurring diseases in animals: contributions to translational medicine. ILAR J. 2014; 55(1):1-3. DOI: 10.1093/ilar/ilu022. View

10.

Vaysse A, Ratnakumar A, Derrien T, Axelsson E, Pielberg G, Sigurdsson S . Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet. 2011; 7(10):e1002316. PMC: 3192833. DOI: 10.1371/journal.pgen.1002316. View

11.

Knoll R, Hoshijima M, Hoffman H, Person V, Lorenzen-Schmidt I, Bang M . The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2003; 111(7):943-55. DOI: 10.1016/s0092-8674(02)01226-6. View

12.

Pasqualucci L, Dalla-Favera R . Genetics of diffuse large B-cell lymphoma. Blood. 2018; 131(21):2307-2319. PMC: 5969374. DOI: 10.1182/blood-2017-11-764332. View

13.

Guyon R, Lorentzen T, Hitte C, Kim L, Cadieu E, Parker H . A 1-Mb resolution radiation hybrid map of the canine genome. Proc Natl Acad Sci U S A. 2003; 100(9):5296-301. PMC: 154339. DOI: 10.1073/pnas.0831002100. View

14.

Lee H, Kim J . The dog as an exercise science animal model: a review of physiological and hematological effects of exercise conditions. Phys Act Nutr. 2021; 24(4):1-6. PMC: 7923746. DOI: 10.20463/pan.2020.0021. View

15.

Karlsson E, Baranowska I, Wade C, Salmon Hillbertz N, Zody M, Anderson N . Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet. 2007; 39(11):1321-8. DOI: 10.1038/ng.2007.10. View

16.

Patterson D . Companion animal medicine in the age of medical genetics. J Vet Intern Med. 2000; 14(1):1-9. View

17.

ONeill D, Brodbelt D, Hodge R, Church D, Meeson R . Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK. Canine Med Genet. 2020; 7:1. PMC: 7371807. DOI: 10.1186/s40575-020-0080-5. View

18.

Larson G, Bradley D . How much is that in dog years? The advent of canine population genomics. PLoS Genet. 2014; 10(1):e1004093. PMC: 3894154. DOI: 10.1371/journal.pgen.1004093. View

19.

Garcia-Rodriguez R, Hiller M, Jimenez-Gracia L, van der Pal Z, Balog J, Adamzek K . Premature termination codons in the gene cause reduced local mRNA synthesis. Proc Natl Acad Sci U S A. 2020; 117(28):16456-16464. PMC: 7368324. DOI: 10.1073/pnas.1910456117. View

20.

Awano T, Katz M, OBrien D, Taylor J, Evans J, Khan S . A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis. Mol Genet Metab. 2006; 87(4):341-8. DOI: 10.1016/j.ymgme.2005.11.005. View