Dual-slope Imaging of Cerebral Hemodynamics with Frequency-domain Near-infrared Spectroscopy

Overview

Journal Neurophotonics

Date 2023 Jan 5

PMID 36601543

Authors

Giles Blaney

Cristianne Fernandez

Angelo Sassaroli

Sergio Fantini

Affiliations

Soon will be listed here.

Abstract

Significance: This work targets the contamination of optical signals by superficial hemodynamics, which is one of the chief hurdles in non-invasive optical measurements of the human brain.

Aim: To identify optimal source-detector distances for dual-slope (DS) measurements in frequency-domain (FD) near-infrared spectroscopy (NIRS) and demonstrate preferential sensitivity of DS imaging to deeper tissue (brain) versus superficial tissue (scalp).

Approach: Theoretical studies () based on diffusion theory in two-layered and in homogeneous scattering media. demonstrations of DS imaging of the human brain during visual stimulation and during systemic blood pressure oscillations.

Results: The mean distance (between the two source-detector distances needed for DS) is the key factor for depth sensitivity. imaging of the human lobe with FD NIRS and a mean distance of 31 mm indicated: (1) greater hemodynamic response to visual stimulation from FD phase versus intensity, and from DS versus single-distance (SD); (2) hemodynamics from FD phase and DS mainly driven by blood flow, and hemodynamics from SD intensity mainly driven by blood volume.

Conclusions: DS imaging with FD NIRS may suppress confounding contributions from superficial hemodynamics without relying on data at short source-detector distances. This capability can have significant implications for non-invasive optical measurements of the human brain.

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