Noncoding RNA Therapeutics for Substance Use Disorder

Overview

Journal Adv Drug Alcohol Res

Specialty Psychiatry

Date 2023 Jan 5

PMID 36601439

Authors

Seyed Afshin Seyednejad

Gregory C Sartor

Affiliations

Soon will be listed here.

Abstract

Although noncoding RNAs (ncRNAs) have been shown to regulate maladaptive neuroadaptations that drive compulsive drug use, ncRNA-targeting therapeutics for substance use disorder (SUD) have yet to be clinically tested. Recent advances in RNA-based drugs have improved many therapeutic issues related to immune response, specificity, and delivery, leading to multiple successful clinical trials for other diseases. As the need for safe and effective treatments for SUD continues to grow, novel nucleic acid-based therapeutics represent an appealing approach to target ncRNA mechanisms in SUD. Here, we review ncRNA processes implicated in SUD, discuss recent therapeutic approaches for targeting ncRNAs, and highlight potential opportunities and challenges of ncRNA-targeting therapeutics for SUD.

Citing Articles

A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics.

Ranjbar S, Zhong X, Manautou J, Lu X Adv Drug Deliv Rev. 2023; 201:115052.

PMID: 37567502 PMC: 10543595. DOI: 10.1016/j.addr.2023.115052.

Nanotechnology Lighting the Way for Gene Therapy in Ophthalmopathy: From Opportunities toward Applications.

Ren W, Duan S, Dai C, Xie C, Jiang L, Shi Y Molecules. 2023; 28(8).

PMID: 37110734 PMC: 10141718. DOI: 10.3390/molecules28083500.

References

Saad M, Rumschlag M, Guerra M, Savonen C, Jaster A, Olson P . Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusers. Sci Rep. 2019; 9(1):1534. PMC: 6367337. DOI: 10.1038/s41598-018-38209-8. View

Shum K, Rossi J . Preface. Methods Mol Biol. 2016; 1364:v-vi. DOI: 10.1007/978-1-4939-3112-5. View

Hong D, Kang Y, Borad M, Sachdev J, Ejadi S, Lim H . Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours. Br J Cancer. 2020; 122(11):1630-1637. PMC: 7251107. DOI: 10.1038/s41416-020-0802-1. View

Ross K, Brenza T, Binnebose A, Phanse Y, Kanthasamy A, Gendelman H . Nano-enabled delivery of diverse payloads across complex biological barriers. J Control Release. 2015; 219:548-559. PMC: 4656048. DOI: 10.1016/j.jconrel.2015.08.039. View

Sztuba-Solinska J, Chavez-Calvillo G, Cline S . Unveiling the druggable RNA targets and small molecule therapeutics. Bioorg Med Chem. 2019; 27(10):2149-2165. PMC: 7126819. DOI: 10.1016/j.bmc.2019.03.057. View

Dirren E, Aebischer J, Rochat C, Towne C, Schneider B, Aebischer P . SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice. Ann Clin Transl Neurol. 2015; 2(2):167-84. PMC: 4338957. DOI: 10.1002/acn3.162. View

Viola T, Heberle B, Zaparte A, Sanvicente-Vieira B, Wainer L, Fries G . Peripheral blood microRNA levels in females with cocaine use disorder. J Psychiatr Res. 2019; 114:48-54. PMC: 6546503. DOI: 10.1016/j.jpsychires.2019.03.028. View

Zhu L, Zhu J, Liu Y, Chen Y, Li Y, Huang L . Methamphetamine induces alterations in the long non-coding RNAs expression profile in the nucleus accumbens of the mouse. BMC Neurosci. 2015; 16:18. PMC: 4399149. DOI: 10.1186/s12868-015-0157-3. View

Deng M, Zhang Z, Xing M, Liang X, Li Z, Wu J . LncRNA MRAK159688 facilitates morphine tolerance by promoting REST-mediated inhibition of mu opioid receptor in rats. Neuropharmacology. 2022; 206:108938. DOI: 10.1016/j.neuropharm.2021.108938. View

10.

Kim M, Bae S, Oh I, Yoo J, Kim J . Sequence-dependent twist-bend coupling in DNA minicircles. Nanoscale. 2021; 13(47):20186-20196. DOI: 10.1039/d1nr04672a. View

11.

Costales M, Aikawa H, Li Y, Childs-Disney J, Abegg D, Hoch D . Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer. Proc Natl Acad Sci U S A. 2020; 117(5):2406-2411. PMC: 7007575. DOI: 10.1073/pnas.1914286117. View

12.

Disney M . Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine. J Am Chem Soc. 2019; 141(17):6776-6790. PMC: 6541398. DOI: 10.1021/jacs.8b13419. View

13.

Teppen T, Krishnan H, Zhang H, Sakharkar A, Pandey S . The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis. Biol Psychiatry. 2016; 80(9):711-719. PMC: 4882267. DOI: 10.1016/j.biopsych.2015.10.028. View

14.

Kim B, Tag S, Kim Y, Cho S, Im H . Circulating microRNA miR-137 as a stable biomarker for methamphetamine abstinence. Psychopharmacology (Berl). 2022; 239(3):831-840. PMC: 8891205. DOI: 10.1007/s00213-022-06074-z. View

15.

Ochoa S, Milam V . Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides. Molecules. 2020; 25(20). PMC: 7587394. DOI: 10.3390/molecules25204659. View

16.

Robbins M, Judge A, Liang L, McClintock K, Yaworski E, MacLachlan I . 2'-O-methyl-modified RNAs act as TLR7 antagonists. Mol Ther. 2007; 15(9):1663-9. DOI: 10.1038/sj.mt.6300240. View

17.

Vornholt E, Drake J, Mamdani M, McMichael G, Taylor Z, Bacanu S . Identifying a novel biological mechanism for alcohol addiction associated with circRNA networks acting as potential miRNA sponges. Addict Biol. 2021; 26(6):e13071. PMC: 8590811. DOI: 10.1111/adb.13071. View

18.

Paudel P, Pierotti C, Lozano E, Amoah S, Gardiner A, Caldwell K . Prenatal Alcohol Exposure Results in Sex-Specific Alterations in Circular RNA Expression in the Developing Mouse Brain. Front Neurosci. 2020; 14:581895. PMC: 7693437. DOI: 10.3389/fnins.2020.581895. View

19.

Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H . The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med. 2011; 17(2):211-5. PMC: 3076220. DOI: 10.1038/nm.2284. View

20.

Van Rooij E, Kauppinen S . Development of microRNA therapeutics is coming of age. EMBO Mol Med. 2014; 6(7):851-64. PMC: 4119351. DOI: 10.15252/emmm.201100899. View