Verification, Analytical Validation and Clinical Validation (V3) of Wearable Dosimeters and Light Loggers

Overview

Journal Digit Health

Specialty Medical Informatics

Date 2023 Jan 5

PMID 36601285

Authors

Manuel Spitschan

Karin Smolders

Benjamin Vandendriessche

Brinnae Bent

Jessie P Bakker

Isaac R Rodriguez-Chavez

Celine Vetter

Affiliations

Soon will be listed here.

Abstract

Background: Light exposure is an important driver and modulator of human physiology, behavior and overall health, including the biological clock, sleep-wake cycles, mood and alertness. Light can also be used as a directed intervention, e.g., in the form of light therapy in seasonal affective disorder (SAD), jetlag prevention and treatment, or to treat circadian disorders. Recently, a system of quantities and units related to the physiological effects of light was standardized by the International Commission on Illumination (CIE S 026/E:2018). At the same time, biometric monitoring technologies (BioMeTs) to capture personalized light exposure were developed. However, because there are currently no standard approaches to evaluate the digital dosimeters, the need to provide a firm framework for the characterization, calibration, and reporting for these digital sensors is urgent.

Objective: This article provides such a framework by applying the principles of , and (V3) as a state-of-the-art approach for tools and standards in digital medicine to light dosimetry.

Results: This article describes opportunities for the use of digital dosimeters for basic research, for monitoring light exposure, and for measuring adherence in both clinical and non-clinical populations to light-based interventions in clinical trials.

Citing Articles

Power analysis for personal light exposure measurements and interventions.

Zauner J, Udovicic L, Spitschan M PLoS One. 2024; 19(12):e0308768.

PMID: 39661605 PMC: 11633969. DOI: 10.1371/journal.pone.0308768.

Protocol for a prospective, multicentre, cross-sectional cohort study to assess personal light exposure.

Guidolin C, Aerts S, Agbeshie G, Akuffo K, Aydin S, Baeza-Moyano D BMC Public Health. 2024; 24(1):3285.

PMID: 39592960 PMC: 11590290. DOI: 10.1186/s12889-024-20206-4.

Wearable Light Loggers in Field Conditions: Corneal Light Characteristics, User Compliance, and Acceptance.

Stefani O, Marek R, Schwarz J, Plate S, Zauner J, Schrader B Clocks Sleep. 2024; 6(4):619-634.

PMID: 39584971 PMC: 11586969. DOI: 10.3390/clockssleep6040042.

Global research on wearable technology applications in healthcare: A data-driven bibliometric analysis.

Meng F, Cui Z, Guo H, Zhang Y, Gu Z, Wang Z Digit Health. 2024; 10:20552076241281210.

PMID: 39347506 PMC: 11439181. DOI: 10.1177/20552076241281210.

Towards an evidence-based integrative lighting score: a proposed multi-level approach.

Stefani O, Schollhorn I, Munch M Ann Med. 2024; 56(1):2381220.

PMID: 39049780 PMC: 11275531. DOI: 10.1080/07853890.2024.2381220.

References

Bhandari K, Mirhajianmoghadam H, Ostrin L . Wearable Sensors for Measurement of Viewing Behavior, Light Exposure, and Sleep. Sensors (Basel). 2021; 21(21). PMC: 8587946. DOI: 10.3390/s21217096. View

Kyba C, Spitschan M . Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105000 UK women in the Generations Study'. Br J Cancer. 2018; 120(2):276-277. PMC: 6342976. DOI: 10.1038/s41416-018-0203-x. View

Davis S, Mirick D, Stevens R . Night shift work, light at night, and risk of breast cancer. J Natl Cancer Inst. 2001; 93(20):1557-62. DOI: 10.1093/jnci/93.20.1557. View

Ruger M, Gordijn M, Beersma D, de Vries B, Daan S . Weak relationships between suppression of melatonin and suppression of sleepiness/fatigue in response to light exposure. J Sleep Res. 2005; 14(3):221-7. DOI: 10.1111/j.1365-2869.2005.00452.x. View

Cao Y, Lan W, Wen L, Li X, Pan L, Wang X . An effectiveness study of a wearable device (Clouclip) intervention in unhealthy visual behaviors among school-age children: A pilot study. Medicine (Baltimore). 2020; 99(2):e17992. PMC: 6959882. DOI: 10.1097/MD.0000000000017992. View

Stampfli J, Schrader B, di Battista C, Hafliger R, Schalli O, Wichmann G . The Light-Dosimeter: A new device to help advance research on the non-visual responses to light. Light Res Technol. 2023; 55(4-5):474-486. PMC: 10353031. DOI: 10.1177/14771535221147140. View

Short M, Gradisar M, Lack L, Wright H, Chatburn A . Estimating adolescent sleep patterns: parent reports versus adolescent self-report surveys, sleep diaries, and actigraphy. Nat Sci Sleep. 2013; 5:23-6. PMC: 3630985. DOI: 10.2147/NSS.S38369. View

Te Kulve M, Schlangen L, van Marken Lichtenbelt W . Early evening light mitigates sleep compromising physiological and alerting responses to subsequent late evening light. Sci Rep. 2019; 9(1):16064. PMC: 6831674. DOI: 10.1038/s41598-019-52352-w. View

Obayashi K, Yamagami Y, Kurumatani N, Saeki K . Bedroom lighting environment and incident diabetes mellitus: a longitudinal study of the HEIJO-KYO cohort. Sleep Med. 2019; 65:1-3. DOI: 10.1016/j.sleep.2019.07.006. View

10.

Figueiro M, Hamner R, Bierman A, Rea M . Comparisons of three practical field devices used to measure personal light exposures and activity levels. Light Res Technol. 2014; 45(4):421-434. PMC: 3892948. DOI: 10.1177/1477153512450453. View

11.

Ancoli-Israel S, Rissling M, Neikrug A, Trofimenko V, Natarajan L, Parker B . Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer. Support Care Cancer. 2011; 20(6):1211-9. PMC: 3192914. DOI: 10.1007/s00520-011-1203-z. View

12.

Stefani O, Cajochen C . Should We Re-think Regulations and Standards for Lighting at Workplaces? A Practice Review on Existing Lighting Recommendations. Front Psychiatry. 2021; 12:652161. PMC: 8155670. DOI: 10.3389/fpsyt.2021.652161. View

13.

Cao D, Barrionuevo P . Estimating photoreceptor excitations from spectral outputs of a personal light exposure measurement device. Chronobiol Int. 2014; 32(2):270-80. PMC: 4355054. DOI: 10.3109/07420528.2014.966269. View

14.

Bracke P, Van de Putte E, Ryckaert W . Comment Concerning the Effects of Light Intensity on Melatonin Suppression in the Review "Light Modulation of Human Clocks, Wake, and Sleep" by A. Prayag et al. Clocks Sleep. 2021; 3(1):181-188. PMC: 7931082. DOI: 10.3390/clockssleep3010011. View

15.

Hebert M, Martin S, Lee C, Eastman C . The effects of prior light history on the suppression of melatonin by light in humans. J Pineal Res. 2002; 33(4):198-203. PMC: 3925650. DOI: 10.1034/j.1600-079x.2002.01885.x. View

16.

Riemersma-van der Lek R, Swaab D, Twisk J, Hol E, Hoogendijk W, van Someren E . Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA. 2008; 299(22):2642-55. DOI: 10.1001/jama.299.22.2642. View

17.

Kwon K, Heo S, Yoo I, Banks A, Chan M, Lee J . Miniaturized, light-adaptive, wireless dosimeters autonomously monitor exposure to electromagnetic radiation. Sci Adv. 2019; 5(12):eaay2462. PMC: 6910837. DOI: 10.1126/sciadv.aay2462. View

18.

Smith J, Kripke D, Elliott J, Youngstedt S . Illumination of upper and middle visual fields produces equivalent suppression of melatonin in older volunteers. Chronobiol Int. 2002; 19(5):883-91. DOI: 10.1081/cbi-120014107. View

19.

Wen L, Cheng Q, Cao Y, Li X, Pan L, Li L . The Clouclip, a wearable device for measuring near-work and outdoor time: validation and comparison of objective measures with questionnaire estimates. Acta Ophthalmol. 2021; 99(7):e1222-e1235. DOI: 10.1111/aos.14785. View

20.

Redline S, Purcell S . Sleep and Big Data: harnessing data, technology, and analytics for monitoring sleep and improving diagnostics, prediction, and interventions-an era for Sleep-Omics?. Sleep. 2021; 44(6). PMC: 8521745. DOI: 10.1093/sleep/zsab107. View