A Double-edged Sword: ROS Related Therapies in the Treatment of Psoriasis

Overview

Journal Asian J Pharm Sci

Date 2023 Jan 5

PMID 36600897

Authors

Jingyi Hu

Qiong Bian

Xiaolu Ma

Yihua Xu

Jianqing Gao

Affiliations

Soon will be listed here.

Abstract

In the onset and progression of psoriasis, redox imbalance is a vital factor. It's widely accepted that too much reactive oxygen species (ROS) always make psoriasis worse. Recent research, however, has shown that the accumulation of ROS is not entirely detrimental, as it helps reduce psoriasis lesions by inhibiting epidermal proliferation and keratinocyte death. As a result, ROS appears to have two opposing effects on the treatment of psoriasis. In this review, the current ROS-related therapies for psoriasis, including basic and clinical research, are presented. Additionally, the design and therapeutic benefits of various drug delivery systems and therapeutic approaches are examined, and a potential balance between anti-oxidative stress and ROS accumulation is also trying to be investigated.

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