Neonatal Imprinting of Alveolar Macrophages Via Neutrophil-derived 12-HETE

Overview

Journal Nature

Specialty Science

Date 2023 Jan 4

PMID 36599368

Authors

Erwan Pernet

Sarah Sun

Nicole Sarden

Saideep Gona

Angela Nguyen

Nargis Khan

Martin Mawhinney

Kim A Tran

Julia Chronopoulos

Dnyandeo Amberkar

Mina Sadeghi

Alexandre Grant

Shradha Wali

Renaud Prevel

Jun Ding

James G Martin

Ajitha Thanabalasuriar

Bryan G Yipp

Luis B Barreiro

Maziar Divangahi

Affiliations

Soon will be listed here.

Abstract

Resident-tissue macrophages (RTMs) arise from embryonic precursors, yet the developmental signals that shape their longevity remain largely unknown. Here we demonstrate in mice genetically deficient in 12-lipoxygenase and 15-lipoxygenase (Alox15 mice) that neonatal neutrophil-derived 12-HETE is required for self-renewal and maintenance of alveolar macrophages (AMs) during lung development. Although the seeding and differentiation of AM progenitors remained intact, the absence of 12-HETE led to a significant reduction in AMs in adult lungs and enhanced senescence owing to increased prostaglandin E production. A compromised AM compartment resulted in increased susceptibility to acute lung injury induced by lipopolysaccharide and to pulmonary infections with influenza A virus or SARS-CoV-2. Our results highlight the complexity of prenatal RTM programming and reveal their dependency on in trans eicosanoid production by neutrophils for lifelong self-renewal.

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