Current Concepts of Kimura Disease: Pathophysiology and Evolution of Treatment

Overview

Journal Arch Craniofac Surg

Date 2023 Jan 3

PMID 36596747

Authors

Woo Ju Kim

Han Koo Kim

Affiliations

Soon will be listed here.

Abstract

Kimura disease (KD) is a chronic inflammatory disorder that frequently involves the subcutaneous tissue of the head and neck regions. It often manifests as regional lymphadenopathy or salivary gland enlargement in the affected area. The histologic architecture of the lymph nodes in KD patients is preserved, while the affected tissues show follicular hyperplasia and eosinophilic infiltration. No single modality has been adopted as an optimal treatment for KD. This article concentrates on the fundamental features of KD and reviews current approaches to its treatment.

Citing Articles

Narrative Review of Genetic and Immunological Mechanisms Involved in the Pathogenesis of Kimura's Disease: New Therapeutic Targets.

Loperfido A, Cavaliere C, Fionda B, Bellocchi G, Masieri S, Caminati M Genes (Basel). 2025; 16(2).

PMID: 40004521 PMC: 11855017. DOI: 10.3390/genes16020194.

Eosinophils and the Head and Neck.

Eskinder H, Zhang Y Head Neck Pathol. 2025; 19(1):24.

PMID: 39998702 PMC: 11861784. DOI: 10.1007/s12105-025-01765-3.

Dupilumab combined with corticosteroid therapy for Kimura disease with multiple systemic masses: a case report and literature review.

Lyu Y, Cui Y, Ma L, Guan L, Wen Z, Huang J Front Immunol. 2024; 15:1492547.

PMID: 39512341 PMC: 11540701. DOI: 10.3389/fimmu.2024.1492547.

Ear lobule reduction using a sub-antitragal groove technique in patients with angiolymphoid hyperplasia with eosinophilia on the earlobe: a case report and literature review.

Moon Y, Kim H, Park H Arch Craniofac Surg. 2024; 25(4):192-196.

PMID: 39019078 PMC: 11374520. DOI: 10.7181/acfs.2023.00598.

Kimura Disease Masquerading as Vascular Malformation - An Interesting Report.

Singh K, Devi S, Raj P, Rajput M Indian J Otolaryngol Head Neck Surg. 2024; 76(1):1071-1074.

PMID: 38440517 PMC: 10909068. DOI: 10.1007/s12070-023-04118-0.

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