Imaging Evaluation of Lymphoma in Pregnancy with Review of Clinical Assessment and Treatment Options

Overview

Journal Abdom Radiol (NY)

Publisher Springer

Specialties Gastroenterology
Radiology

Date 2023 Jan 3

PMID 36595067

Authors

Kevin DellAquila

Hannah Hodges

Mariam Moshiri

Douglas S Katz

Saeed Elojeimy

Margarita V Revzin

Miltiadis Tembelis

Jonathan W Revels

Affiliations

Soon will be listed here.

Abstract

Lymphoma-related malignancies can be categorized as Hodgkin's lymphoma (HL) or non-Hodgkin's lymphoma (NHL) based on histologic characteristics. Although quite rare during pregnancy, HL and NHL are the fourth and fifth most common malignancies during the pregnancy period, respectively. Given the rarity of lymphoma among pregnant patients, radiologists are usually unfamiliar with the modifications required for staging and treatment of this population, even those who work at centers with busy obstetrical services. Therefore, this manuscript serves to not only review the abdominopelvic imaging features of lymphoma in pregnancy, but it also discusses topics including birthing parent and fetal lymphoma-related prognosis, both antenatal and postpartum, current concepts in the management of pregnancy-related lymphoma, as well as the current considerations regarding birthing parent onco-fertility.

References

Mafra A, Laversanne M, Gospodarowicz M, Klinger P, de Paula Silva N, Pineros M . Global patterns of non-Hodgkin lymphoma in 2020. Int J Cancer. 2022; 151(9):1474-1481. DOI: 10.1002/ijc.34163. View

Lishner M, Avivi I, Apperley J, Dierickx D, Evens A, Fumagalli M . Hematologic Malignancies in Pregnancy: Management Guidelines From an International Consensus Meeting. J Clin Oncol. 2015; 34(5):501-8. DOI: 10.1200/JCO.2015.62.4445. View

Toma P, Granata C, Rossi A, Garaventa A . Multimodality imaging of Hodgkin disease and non-Hodgkin lymphomas in children. Radiographics. 2007; 27(5):1335-54. DOI: 10.1148/rg.275065157. View

Gurevich-Shapiro A, Avivi I . Current treatment of lymphoma in pregnancy. Expert Rev Hematol. 2019; 12(6):449-459. DOI: 10.1080/17474086.2019.1615878. View

Glaser S, Clarke C, Nugent R, Stearns C, Dorfman R . Reproductive factors in Hodgkin's disease in women. Am J Epidemiol. 2003; 158(6):553-63. DOI: 10.1093/aje/kwg198. View

Yakimchuk K, Jondal M, Okret S . Estrogen receptor α and β in the normal immune system and in lymphoid malignancies. Mol Cell Endocrinol. 2013; 375(1-2):121-9. DOI: 10.1016/j.mce.2013.05.016. View

Marie E, Navallas M, Katz D, Farajirad E, Punnett A, Davda S . Non-Hodgkin Lymphoma Imaging Spectrum in Children, Adolescents, and Young Adults. Radiographics. 2022; 42(4):1214-1238. DOI: 10.1148/rg.210162. View

Kane E, Roman E, Becker N, Bernstein L, Boffetta P, Bracci P . Menstrual and reproductive factors, and hormonal contraception use: associations with non-Hodgkin lymphoma in a pooled analysis of InterLymph case-control studies. Ann Oncol. 2012; 23(9):2362-2374. PMC: 3425371. DOI: 10.1093/annonc/mds171. View

Thomas A, Vaidhyanath R, Kirke R, Rajesh A . Extranodal lymphoma from head to toe: part 1, the head and spine. AJR Am J Roentgenol. 2011; 197(2):350-6. DOI: 10.2214/AJR.10.7266. View

10.

Thomas A, Vaidhyanath R, Kirke R, Rajesh A . Extranodal lymphoma from head to toe: part 2, the trunk and extremities. AJR Am J Roentgenol. 2011; 197(2):357-64. DOI: 10.2214/AJR.11.6738. View

11.

Bligh M, Borgaonkar J, Burrell S, MacDonald D, Manos D . Spectrum of CT Findings in Thoracic Extranodal Non-Hodgkin Lymphoma. Radiographics. 2017; 37(2):439-461. DOI: 10.1148/rg.2017160077. View

12.

Das J, Ray S, Sen S, Chandy M . Extranodal involvement in lymphoma - A Pictorial Essay and Retrospective Analysis of 281 PET/CT studies. Asia Ocean J Nucl Med Biol. 2016; 2(1):42-56. PMC: 4937711. View

13.

Frampas E . Lymphomas: Basic points that radiologists should know. Diagn Interv Imaging. 2013; 94(2):131-44. DOI: 10.1016/j.diii.2012.11.006. View

14.

Vannata B, Zucca E . Primary extranodal B-cell lymphoma: current concepts and treatment strategies. Chin Clin Oncol. 2015; 4(1):10. DOI: 10.3978/j.issn.2304-3865.2014.12.01. View

15.

Evens A, Advani R, Press O, Lossos I, Vose J, Hernandez-Ilizaliturri F . Lymphoma occurring during pregnancy: antenatal therapy, complications, and maternal survival in a multicenter analysis. J Clin Oncol. 2013; 31(32):4132-9. DOI: 10.1200/JCO.2013.49.8220. View

16.

Weibull C, Eloranta S, Smedby K, Bjorkholm M, Kristinsson S, Johansson A . Pregnancy and the Risk of Relapse in Patients Diagnosed With Hodgkin Lymphoma. J Clin Oncol. 2015; 34(4):337-44. DOI: 10.1200/JCO.2015.63.3446. View

17.

Patel S, Sweeney L . Maternal Health in the Transgender Population. J Womens Health (Larchmt). 2020; 30(2):253-259. DOI: 10.1089/jwh.2020.8880. View

18.

Johnson S, Kumar A, Matasar M, Schoder H, Rademaker J . Imaging for Staging and Response Assessment in Lymphoma. Radiology. 2015; 276(2):323-38. DOI: 10.1148/radiol.2015142088. View

19.

de Boer M, van Deurzen C, van Dijck J, Borm G, van Diest P, Adang E . Micrometastases or isolated tumor cells and the outcome of breast cancer. N Engl J Med. 2009; 361(7):653-63. DOI: 10.1056/NEJMoa0904832. View

20.

Cui X, Jenssen C, Saftoiu A, Ignee A, Dietrich C . New ultrasound techniques for lymph node evaluation. World J Gastroenterol. 2013; 19(30):4850-60. PMC: 3740414. DOI: 10.3748/wjg.v19.i30.4850. View