Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2023 Jan 3

PMID 36594094

Authors

Zeyi Lu

Yuanlei Chen

Wenqin Luo

Lifeng Ding

Huan Wang

Yang Li

Bo Wen Yang

Liangliang Ren

Qiming Zheng

Haiyun Xie

Ruyue Wang

Chenhao Yu

Yudong Lin

Zhenwei Zhou

Liqun Xia

Gonghui Li

Affiliations

Soon will be listed here.

Abstract

Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.

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