A Review of Recent Advances in Exosomes and Allergic Rhinitis

Overview

Journal Front Pharmacol

Date 2023 Jan 2

PMID 36588711

Authors

Zhong Zheng

Yangyang Yu

Affiliations

Soon will be listed here.

Abstract

Allergic rhinitis is a chronic inflammatory disease of nasal mucosa caused by the presence of IgE after exposure to allergens, characterized by nasal irritation, hypersecretion of the nasal passages and sneezing, which frequently occurs in children and adolescents. There has been an increase in allergic rhinitis over the past few years due to air pollution. Exosomes have been discovered to be nano-sized vesicles, which contain a wide range of substances, including proteins and nucleic acids, numerous studies indicates that exosomes play a vital role in cells communication. Recently there have been more and more studies exploring the role of exosomes in allergic rhinitis. Therefore, here we will present a comprehensive review of the research on exosomes and their role in allergic rhinitis for the purpose of providing new understanding of potential value of exosomes applied to the treatment of allergic rhinitis.

Citing Articles

Effect of adipose mesenchymal stem cell-derived exosomes on allergic rhinitis in mice.

Xu X, Li C, Qin Q, Han F, Wang Y Heliyon. 2025; 11(1):e41340.

PMID: 39816505 PMC: 11732663. DOI: 10.1016/j.heliyon.2024.e41340.

Serum exosomal miR-141-3p and miR-3679-5p levels associated with endotype and postoperative recurrence in chronic rhinosinusitis with nasal polyps.

Wang G, Liu Z, Zhan J, Li R, Ye Y, Qi Y World Allergy Organ J. 2024; 17(8):100938.

PMID: 39156601 PMC: 11327455. DOI: 10.1016/j.waojou.2024.100938.

Improving Pharmacokinetics of Peptides Using Phage Display.

Asar M, Newton-Northup J, Soendergaard M Viruses. 2024; 16(4).

PMID: 38675913 PMC: 11055145. DOI: 10.3390/v16040570.

Role of dendritic cell‑derived exosomes in allergic rhinitis (Review).

Kang C, He H, Liu P, Liu Y, Li X, Zhang J Int J Mol Med. 2023; 52(6).

PMID: 37888754 PMC: 10635688. DOI: 10.3892/ijmm.2023.5320.

High mobility group box-1: a potential therapeutic target for allergic rhinitis.

Wu S, Yu Y, Zheng Z, Cheng Q Eur J Med Res. 2023; 28(1):430.

PMID: 37828579 PMC: 10571310. DOI: 10.1186/s40001-023-01412-z.

References

Zhang Y, Lan F, Zhang L . Update on pathomechanisms and treatments in allergic rhinitis. Allergy. 2022; 77(11):3309-3319. DOI: 10.1111/all.15454. View

Robak E, Dziankowska B, Torzecka D, Chojnowski K, Robak T . Association of interferon gamma, tumor necrosis factor alpha and interleukin 6 serum levels with systemic lupus erythematosus activity. Arch Immunol Ther Exp (Warsz). 1999; 46(6):375-80. View

Harrell C, Volarevic A, Djonov V, Volarevic V . Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders. Int J Mol Sci. 2021; 22(3). PMC: 7867043. DOI: 10.3390/ijms22031433. View

Kalluri R, LeBleu V . The biology function and biomedical applications of exosomes. Science. 2020; 367(6478). PMC: 7717626. DOI: 10.1126/science.aau6977. View

Riazifar M, Mohammadi M, Pone E, Yeri A, Lasser C, Segaliny A . Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders. ACS Nano. 2019; 13(6):6670-6688. PMC: 6880946. DOI: 10.1021/acsnano.9b01004. View

Gunawan M, Venkatesan N, Loh J, Wong J, Berger H, Neo W . The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat Immunol. 2015; 16(5):505-16. DOI: 10.1038/ni.3125. View

Shen J, Zhu X, Fei J, Shi P, Yu S, Zhou J . Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect. Onco Targets Ther. 2018; 11:2831-2841. PMC: 5961474. DOI: 10.2147/OTT.S159829. View

Shekari F, Nazari A, Kashani S, Hajizadeh-Saffar E, Lim R, Baharvand H . Pre-clinical investigation of mesenchymal stromal cell-derived extracellular vesicles: a systematic review. Cytotherapy. 2021; 23(4):277-284. DOI: 10.1016/j.jcyt.2020.12.009. View

Siles-Lucas M, Morchon R, Simon F, Manzano-Roman R . Exosome-transported microRNAs of helminth origin: new tools for allergic and autoimmune diseases therapy?. Parasite Immunol. 2015; 37(4):208-14. DOI: 10.1111/pim.12182. View

10.

Qiu S, Du Y, Duan X, Geng X, Xie J, Gao H . Cytotoxic T lymphocytes mediate chronic inflammation of the nasal mucosa of patients with atypical allergic rhinitis. N Am J Med Sci. 2011; 3(8):378-83. PMC: 3234139. DOI: 10.4297/najms.2011.3378. View

11.

Sanai A, Nagata H, Konno A . Extensive interstitial collagen deposition on the basement membrane zone in allergic nasal mucosa. Acta Otolaryngol. 1999; 119(4):473-8. DOI: 10.1080/00016489950181026. View

12.

Sun R, Yang Y, Gu Z, Tang X, Zhang C, Kou W . Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro. Mol Med Rep. 2019; 20(4):3893-3900. DOI: 10.3892/mmr.2019.10638. View

13.

Izuhara K, Nunomura S, Nanri Y, Ono J, Takai M, Kawaguchi A . Periostin: An emerging biomarker for allergic diseases. Allergy. 2019; 74(11):2116-2128. DOI: 10.1111/all.13814. View

14.

Zhu X, Wang X, Wang Y, Zhao Y . Exosomal long non-coding RNA GAS5 suppresses Th1 differentiation and promotes Th2 differentiation via downregulating EZH2 and T-bet in allergic rhinitis. Mol Immunol. 2019; 118:30-39. DOI: 10.1016/j.molimm.2019.11.009. View

15.

Li J, Du Y, Yan Z, Yan J, Zhuansun Y, Chen R . CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice. Exp Ther Med. 2016; 11(3):878-884. PMC: 4774365. DOI: 10.3892/etm.2016.2989. View

16.

Harrell C, Jovicic N, Djonov V, Arsenijevic N, Volarevic V . Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases. Cells. 2019; 8(12). PMC: 6952783. DOI: 10.3390/cells8121605. View

17.

Mims J . Epidemiology of allergic rhinitis. Int Forum Allergy Rhinol. 2014; 4 Suppl 2:S18-20. DOI: 10.1002/alr.21385. View

18.

Zhang L, Yu D . Exosomes in cancer development, metastasis, and immunity. Biochim Biophys Acta Rev Cancer. 2019; 1871(2):455-468. PMC: 6542596. DOI: 10.1016/j.bbcan.2019.04.004. View

19.

Li M, Liu L, Dong M . Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis. Mol Cancer. 2021; 20(1):22. PMC: 7839206. DOI: 10.1186/s12943-021-01312-y. View

20.

Park S, Jun Y, Kim T, Jung J, Hwang G, Jung K . Increased expression of YKL-40 in mild and moderate/severe persistent allergic rhinitis and its possible contribution to remodeling of nasal mucosa. Am J Rhinol Allergy. 2013; 27(5):372-80. DOI: 10.2500/ajra.2013.27.3941. View