Nanoformulation of Lipophilic Osmium Photosensitizers in Liposomes and Micelles As a General Strategy for Improving Reproducibility and Reducing Quenching
Overview
Overview
Journal
Photochem Photobiol
Specialties
Biochemistry
Biology
Chemistry
Biology
Chemistry
Date
2023 Jan 2
PMID
36588328
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Nanoformulation of an osmium photosensitizer within liposomes and micelles is used to improve the water-solubility of this highly lipophilic molecule. This highlight report describes a recent paper by Cameron, Obaid and McFarland on this topic and discusses the context for this report. Nanoformulation has been explored as a strategy before, but this represents the first usage of this strategy with highly potent metal-based photosensitizers having phototherapeutic indices (PIs) in excess of 10 . The nanoformulation strategy is effective due to reducing aggregation and self-quenching of the photosensitizer molecules.
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