Is There a Role for Herpes Simplex Virus Type 1 in Multiple Sclerosis?

Overview

Journal Microbes Infect

Publisher Elsevier

Specialties Allergy & Immunology
Microbiology

Date 2022 Dec 31

PMID 36586461

Authors

Luisa F Duarte

Sebastian Gatica

Almendra Castillo

Alexis M Kalergis

Susan M Bueno

Claudia A Riedel

Pablo A Gonzalez

Affiliations

Soon will be listed here.

Abstract

Numerous studies relate the onset and severity of multiple sclerosis (MS) with viral infections. Herpes simplex virus type 1 (HSV-1), which is neurotropic and highly prevalent in the brain of healthy individuals, has been proposed to relate to MS. Here, we review and discuss the reported connections between HSV-1 and MS.

Citing Articles

Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease.

Duarte L, Villalobos V, Farias M, Rangel-Ramirez M, Gonzalez-Madrid E, Navarro A Commun Biol. 2024; 7(1):811.

PMID: 38965360 PMC: 11224417. DOI: 10.1038/s42003-024-06486-x.

Cytomegalovirus, Epstein-Barr Virus, Herpes Simplex Virus, and Varicella Zoster Virus Infection Dynamics in People with Multiple Sclerosis from Northern Italy.

Maple P, Tanasescu R, Constantinescu C, Valentino P, Capobianco M, DOrso S Pathogens. 2024; 13(6).

PMID: 38921797 PMC: 11206421. DOI: 10.3390/pathogens13060499.

Herpes Simplex Virus type 1 inhibits autophagy in glial cells but requires ATG5 for the success of viral replication.

Ripa I, Andreu S, Josa-Prado F, Fernandez Gomez B, de Castro F, Arribas M Front Microbiol. 2024; 15:1411655.

PMID: 38915300 PMC: 11194409. DOI: 10.3389/fmicb.2024.1411655.

Negative association between multiple sclerosis immunogenetic profile and in silico immunogenicities of 12 viruses.

James L, Georgopoulos A Sci Rep. 2023; 13(1):18654.

PMID: 37907711 PMC: 10618254. DOI: 10.1038/s41598-023-45931-5.

Contribution of viral and bacterial infections to senescence and immunosenescence.

Reyes A, Ortiz G, Duarte L, Fernandez C, Hernandez-Armengol R, Palacios P Front Cell Infect Microbiol. 2023; 13:1229098.

PMID: 37753486 PMC: 10518457. DOI: 10.3389/fcimb.2023.1229098.