Gene-environment Interactions and Their Impact on Human Health

Overview

Journal Genes Immun

Date 2022 Dec 30

PMID 36585519

Authors

Samuel J Virolainen

Andrew VonHandorf

Kenyatta C M F Viel

Matthew T Weirauch

Leah C Kottyan

Affiliations

Soon will be listed here.

Abstract

The molecular processes underlying human health and disease are highly complex. Often, genetic and environmental factors contribute to a given disease or phenotype in a non-additive manner, yielding a gene-environment (G × E) interaction. In this work, we broadly review current knowledge on the impact of gene-environment interactions on human health. We first explain the independent impact of genetic variation and the environment. We next detail well-established G × E interactions that impact human health involving environmental toxicants, pollution, viruses, and sex chromosome composition. We conclude with possibilities and challenges for studying G × E interactions.

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