Recent Advances in Gas-phase Ion/Ion Chemistry for Lipid Analysis

Overview

Journal Trends Analyt Chem

Specialty Chemistry

Date 2022 Dec 30

PMID 36583222

Authors

Hsi-Chun Chao

Scott A McLuckey

Affiliations

Soon will be listed here.

Abstract

Gas-phase ion/ion reactions can be used to alter analyte ion-types for subsequent dissociation both quickly and efficiently without the need for altering analyte ionization conditions. This capability can be particularly useful when the ion-type that is most efficiently generated by the ionization method at hand does not provide the structural information of interest using available dissociation methods. This situation often arises in the analysis of lipids, which constitute a diverse array of chemical species with many possibilities for isomers. Gas-phase ion/ion reactions have been demonstrated to be capable of enhancing the ability of tandem mass spectrometry to characterize the structures of various lipid classes. This review summarizes progress to date in the application of gas-phase ion/ion reactions to lipid structural characterization.

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