The Ethanolic Extract of Lindera Aggregata Modulates Gut Microbiota Dysbiosis and Alleviates Ethanol-Induced Acute Liver Inflammation and Oxidative Stress SIRT1/Nrf2/NF-B Pathway

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2022 Dec 30

PMID 36583098

Authors

Xin Zhao

Mingming Tan

Yichen He

Yi Pan

Xinli Fan

Luyi Ye

Longcai Liu

Luoqin Fu

Affiliations

Soon will be listed here.

Abstract

This study is an attempt to evaluate the therapeutic effect of the ethanolic extract of on the liver and intestinal microbiota in rats with alcohol-induced liver injury (ALI). Rats were treated with 70 mg probiotics, 1 g/kg, 2 g/kg, and 3 g/kg ethanolic extract of , respectively, for 10 days. We found that could significantly reduce the biochemical parameters in the serum of ALD rats. alleviates oxidative stress and inflammation by upregulating SIRT1 and Nrf2 and downregulating COX2 and NF-B. The results of 16S rRNA gene sequencing showed that the medium dose of had the best effect on the growth of beneficial bacteria. Diversity analysis and LEfSe analysis showed that beneficial bacteria gradually occupied the dominant niche. The relative abundance of potential pathogens in the gut decreased significantly. We demonstrated that the ethanolic extract of can alleviate the oxidative stress and inflammation induced by alcohol through the SIRT1/Nrf2/NF-B pathway and can modulate the disturbance of gut microbiota induced by alcohol intake.

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