Construction of Multifunctional Hydrogel with Metal-polyphenol Capsules for Infected Full-thickness Skin Wound Healing

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2022 Dec 30

PMID 36582352

Authors

Nanbo Liu

Shuoji Zhu

Yuzhi Deng

Ming Xie

Mingyi Zhao

Tucheng Sun

Changjiang Yu

Ying Zhong

Rui Guo

Keluo Cheng

Dehua Chang

Ping Zhu

Affiliations

Soon will be listed here.

Abstract

Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate (Cu-EGCG) nano-capsules. The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on and . It could also promote the proliferation and migration of L929 fibroblasts. full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect. Accelerate collagen deposition and wound healing speed were also observed in the SilMA/HAMA/Cu-EGCG hydrogel treated group. The findings of this study show the great potential of this controlled-release antibacterial composite hydrogel in the application of chronic wound healing.

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