Clinicopathological and Prognostic Significance of COX-2 in Glioma Patients: a Meta-analysis

Overview

Journal Arq Neuropsiquiatr

Publisher Thieme

Specialties Neurology
Psychiatry

Date 2022 Dec 29

PMID 36580964

Authors

Jun Wang

Chenyan Xiang

Yi Cai

Ziyi Mei

Qianqian Lu

Binbin Liu

Lili Zou

Affiliations

Soon will be listed here.

Abstract

Background: In recent years, cyclooxygenase-2 (COX-2) has been identified as a cancer stem cell (CSC) marker in gliomas. Nevertheless, the clinical and prognostic significance of COX-2 in glioma patients remains controversial.

Objective: To evaluate the correlation of COX-2 with the prognosis in glioma patients.

Methods: Eligible studies on this subject were included, and pooled odd ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated. Publication bias was assessed through funnel plots, and heterogeneity and sensitivity were analyzed as well.

Results: In the present study, 11 articles with a total of 641 patients were included. The high expression of COX-2 in glioma patients was negatively associated with overall survival (OS) (n = 11; HR = 2.26; 95%CI = 1.79-2.86), and the subgroup analysis showed no differences in OS between Asian (n = 5; HR = 2.16; 95%CI = 1.57-2.97) and non-Asian (n = 6; HR = 2.39; 95%CI = 1.69-3.38) glioma patients. The Begg funnel plots test indicated that there was no evident risk of publication bias in the meta-analysis.

Conclusion: The present study suggests that COX-2 could be recommended as a useful pathological and prognostic biomarker in the clinical practice.

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