Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia

Overview

Journal Dokl Biochem Biophys

Specialties Biochemistry
Biophysics

Date 2022 Dec 29

PMID 36580212

Authors

K A Artemieva

N V Nizyaeva

O R Baev

A Yu Romanov

G V Khlestova

M N Boltovskaya

A I Shchegolev

L V Kakturskiy

Affiliations

Soon will be listed here.

Abstract

Preeclampsia (PE) is one of the most dangerous complications of pregnancy, characterized by hypertension, proteinuria, and symptoms of multiple organ failure, which are detected de novo after 20 weeks of pregnancy. The renin-angiotensin-aldosterone system (RAAS) is one of the first to recognize pregnancy and is an important regulator of blood pressure. The placenta has its own RAAS, the role of which in the development of PE is not fully understood. In this work, for the first time, we characterized the expression of RAAS components and miRNAs controlling it in the placenta at various times of PE manifestation. The data obtained will allow the development of a new strategy in the future for the search for therapeutic agents for patients suffering from PE and cardiovascular diseases.

Citing Articles

Renal Function and the Role of the Renin-Angiotensin-Aldosterone System (RAAS) in Normal Pregnancy and Pre-Eclampsia.

Tsikouras P, Nikolettos K, Kotanidou S, Kritsotaki N, Oikonomou E, Bothou A J Clin Med. 2025; 14(3).

PMID: 39941563 PMC: 11818630. DOI: 10.3390/jcm14030892.

Association of ACE*(Insertion/Deletion) Variant with the Elevated Risk of Preeclampsia Among Gestational Women.

El Azab E, Abd El-Kader R, Elhassan T, Mohammed Ali S, Shaaban E, El-Eshmawy M Biochem Genet. 2024; 62(5):3774-3802.

PMID: 38219243 DOI: 10.1007/s10528-023-10620-5.

Approach to the Patient: Reninoma.

Hayes A, Stowasser M, Umapathysivam M, Falhammar H, Torpy D J Clin Endocrinol Metab. 2023; 109(2):e809-e816.

PMID: 37647894 PMC: 10795928. DOI: 10.1210/clinem/dgad516.

References

Pringle K, Tadros M, Callister R, Lumbers E . The expression and localization of the human placental prorenin/renin-angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis?. Placenta. 2011; 32(12):956-62. DOI: 10.1016/j.placenta.2011.09.020. View

Lumbers E, Pringle K . Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy. Am J Physiol Regul Integr Comp Physiol. 2013; 306(2):R91-101. DOI: 10.1152/ajpregu.00034.2013. View

Fushima T, Sekimoto A, Minato T, Ito T, Oe Y, Kisu K . Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice. PLoS One. 2016; 11(5):e0155426. PMC: 4871336. DOI: 10.1371/journal.pone.0155426. View

Improta-Caria A, Aras M, Nascimento L, De Sousa R, Aras-Junior R, Souza B . MicroRNAs Regulating Renin-Angiotensin-Aldosterone System, Sympathetic Nervous System and Left Ventricular Hypertrophy in Systemic Arterial Hypertension. Biomolecules. 2021; 11(12). PMC: 8698399. DOI: 10.3390/biom11121771. View

Nemecz M, Alexandru N, Tanko G, Georgescu A . Role of MicroRNA in Endothelial Dysfunction and Hypertension. Curr Hypertens Rep. 2016; 18(12):87. PMC: 7102349. DOI: 10.1007/s11906-016-0696-8. View

Yang J, Shang J, Zhang S, Li H, Liu H . The role of the renin-angiotensin-aldosterone system in preeclampsia: genetic polymorphisms and microRNA. J Mol Endocrinol. 2013; 50(2):R53-66. DOI: 10.1530/JME-12-0216. View

Khlestova G, Romanov A, Nizyaeva N, Karapetyan A, Baev O, Ivanets T . Dynamics of Renin, Angiotensin II, and Angiotensin (1-7) during Pregnancy and Predisposition to Hypertension-Associated Complications. Bull Exp Biol Med. 2018; 165(4):438-439. DOI: 10.1007/s10517-018-4188-5. View

Aneman I, Pienaar D, Suvakov S, Simic T, Garovic V, McClements L . Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia. Front Immunol. 2020; 11:1864. PMC: 7462000. DOI: 10.3389/fimmu.2020.01864. View

Nizyaeva N, Kulikova G, Nagovitsyna M, Kan N, Prozorovskaya K, Shchegolev A . Expression of MicroRNA-146a and MicroRNA-155 in Placental Villi in Early- and Late-Onset Preeclampsia. Bull Exp Biol Med. 2017; 163(3):394-399. DOI: 10.1007/s10517-017-3812-0. View

10.

Pankiewicz K, Fijalkowska A, Issat T, Maciejewski T . Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs. Int J Mol Sci. 2021; 22(6). PMC: 8003365. DOI: 10.3390/ijms22063132. View

11.

Barbosa I, Silva W, Cerqueira G, Novo N, Almeida F, Novo J . Maternal and fetal outcome in women with hypertensive disorders of pregnancy: the impact of prenatal care. Ther Adv Cardiovasc Dis. 2015; 9(4):140-6. DOI: 10.1177/1753944715597622. View

12.

Roganovic J . Downregulation of microRNA-146a in diabetes, obesity and hypertension may contribute to severe COVID-19. Med Hypotheses. 2020; 146:110448. PMC: 7836676. DOI: 10.1016/j.mehy.2020.110448. View

13.

Arthurs A, Lumbers E, Pringle K . MicroRNA mimics that target the placental renin-angiotensin system inhibit trophoblast proliferation. Mol Hum Reprod. 2019; 25(4):218-227. DOI: 10.1093/molehr/gaz010. View

14.

Sandgren J, Scroggins S, Santillan D, Devor E, Gibson-Corley K, Pierce G . Vasopressin: the missing link for preeclampsia?. Am J Physiol Regul Integr Comp Physiol. 2015; 309(9):R1062-4. PMC: 4666952. DOI: 10.1152/ajpregu.00073.2015. View

15.

Singh S, Moodley J, Khaliq O, Naicker T . A Narrative Review of the Renin-Angiotensin-Aldosterone System in the Placenta and Placental Bed of HIV Infected Women of African Ancestry with Preeclampsia. Curr Hypertens Rep. 2021; 23(8):39. PMC: 8377458. DOI: 10.1007/s11906-021-01158-1. View

16.

Rucker A, Crowley S . The role of macrophages in hypertension and its complications. Pflugers Arch. 2017; 469(3-4):419-430. PMC: 5773253. DOI: 10.1007/s00424-017-1950-x. View

17.

Navar L . Intrarenal renin-angiotensin system in regulation of glomerular function. Curr Opin Nephrol Hypertens. 2013; 23(1):38-45. PMC: 3982859. DOI: 10.1097/01.mnh.0000436544.86508.f1. View