in the Treatment of Symptomatic Oral Lichen Planus: A Non-randomized Controlled Trial

Overview

Journal Indian J Dermatol

Specialty Dermatology

Date 2022 Dec 29

PMID 36578734

Authors

Tanya Khaitan

Vishal

Arpita Kabiraj

Dharmendra Kumar Sinha

Rajeev Ranjan

Rakhi Singh

Affiliations

Soon will be listed here.

Abstract

Introduction: Oxidative stress has been suggested as pathogenesis of oral lichen planus (OLP), implicating the vital role of antioxidants in its treatment. Curcumin, naturally found in turmeric has potent antioxidant and inflammatory properties and can be useful in reducing spread and subsiding burning and pain sensation in patients with OLP. The present study was done to evaluate the role of curcumin in the treatment of symptomatic OLP compared with the control group.

Materials And Method: A total of 40 patients with symptomatic OLP were divided into 2 groups of 20 subjects each. Group A was treated with curcumin oral gel and a multivitamin capsule containing zinc, whereas Group B was given multivitamin containing zinc only. Patients were followed-up twice, that is, after 1 month and 3 months. A modified REU (reticulation/keratosis, erythema and ulceration) score for spread and Visual analogue scale for pain/burning sensation was used and the difference of score was calculated by t test.

Results: During F1 period, 0.61 (Group A) and 0.19 (Group B) points improvement and in F2 period, the REU score further increased significantly to 1.36 (Group A) and 0.43 (Group B), respectively. The mean score reduction in Visual analogue scale during F1 period was 1.71 and 0.71, which further increased significantly to 2.88 and 1.24 during F2 period in Groups A and B, respectively.

Conclusion: Curcumin, an active ingredient of turmeric is commercially available in gel form to treat different oral lesions and significantly effective in reducing spread and providing symptomatic relief in OLP without any adverse effects.

Citing Articles

Integrative Approaches for the Diagnosis and Management of Erosive Oral Lichen Planus.

Popa C, Sciuca A, Onofrei B, Toader S, Condurache Hritcu O, Botoc Colac C Diagnostics (Basel). 2024; 14(7).

PMID: 38611605 PMC: 11011293. DOI: 10.3390/diagnostics14070692.

References

Singh V, Pal M, Gupta S, Tiwari S, Malkunje L, Das S . Turmeric - A new treatment option for lichen planus: A pilot study. Natl J Maxillofac Surg. 2014; 4(2):198-201. PMC: 3961895. DOI: 10.4103/0975-5950.127651. View

Farjana H, Chandrasekaran S, Gita B . Effect of oral curcuma gel in gingivitis management - a pilot study. J Clin Diagn Res. 2015; 8(12):ZC08-10. PMC: 4316326. DOI: 10.7860/JCDR/2014/8784.5235. View

Davari P, Hsiao H, Fazel N . Mucosal lichen planus: an evidence-based treatment update. Am J Clin Dermatol. 2014; 15(3):181-95. DOI: 10.1007/s40257-014-0068-6. View

Park H, Hurwitz S, Woo S . Oral lichen planus: REU scoring system correlates with pain. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012; 114(1):75-82. DOI: 10.1016/j.oooo.2012.02.013. View

Carrozzo M, Uboldi de Capei M, Dametto E, Fasano M, Arduino P, Broccoletti R . Tumor necrosis factor-alpha and interferon-gamma polymorphisms contribute to susceptibility to oral lichen planus. J Invest Dermatol. 2004; 122(1):87-94. DOI: 10.1046/j.0022-202X.2003.22108.x. View

Xia J, Li C, Hong Y, Yang L, Huang Y, Cheng B . Short-term clinical evaluation of intralesional triamcinolone acetonide injection for ulcerative oral lichen planus. J Oral Pathol Med. 2006; 35(6):327-31. DOI: 10.1111/j.1600-0714.2006.00441.x. View

Kuttan R, Sudheeran P, Josph C . Turmeric and curcumin as topical agents in cancer therapy. Tumori. 1987; 73(1):29-31. DOI: 10.1177/030089168707300105. View

Kia S, Shirazian S, Mansourian A, Khodadadi Fard L, Ashnagar S . Comparative Efficacy of Topical Curcumin and Triamcinolone for Oral Lichen Planus: A Randomized, Controlled Clinical Trial. J Dent (Tehran). 2016; 12(11):789-96. PMC: 4977402. View

Axell T, Rundquist L . Oral lichen planus--a demographic study. Community Dent Oral Epidemiol. 1987; 15(1):52-6. DOI: 10.1111/j.1600-0528.1987.tb00480.x. View

10.

Andreasen J . Oral lichen planus. 1. A clinical evaluation of 115 cases. Oral Surg Oral Med Oral Pathol. 1968; 25(1):31-42. DOI: 10.1016/0030-4220(68)90194-1. View

11.

Haefeli M, Elfering A . Pain assessment. Eur Spine J. 2005; 15 Suppl 1:S17-24. PMC: 3454549. DOI: 10.1007/s00586-005-1044-x. View

12.

Potts A, Hamburger J, Scully C . The medication of patients with oral lichen planus and the association of nonsteroidal anti-inflammatory drugs with erosive lesions. Oral Surg Oral Med Oral Pathol. 1987; 64(5):541-3. DOI: 10.1016/0030-4220(87)90029-6. View

13.

Decani S, Federighi V, Baruzzi E, Sardella A, Lodi G . Iatrogenic Cushing's syndrome and topical steroid therapy: case series and review of the literature. J Dermatolog Treat. 2012; 25(6):495-500. DOI: 10.3109/09546634.2012.755252. View

14.

Ak T, Gulcin I . Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact. 2008; 174(1):27-37. DOI: 10.1016/j.cbi.2008.05.003. View

15.

Deshmukh R, Bagewadi A . Comparison of effectiveness of curcumin with triamcinolone acetonide in the gel form in treatment of minor recurrent aphthous stomatitis: A randomized clinical trial. Int J Pharm Investig. 2014; 4(3):138-41. PMC: 4131385. DOI: 10.4103/2230-973X.138346. View

16.

Olson M, Rogers 3rd R, Bruce A . Oral lichen planus. Clin Dermatol. 2016; 34(4):495-504. DOI: 10.1016/j.clindermatol.2016.02.023. View

17.

Piboonniyom S, Treister N, Pitiphat W, Woo S . Scoring system for monitoring oral lichenoid lesions: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99(6):696-703. DOI: 10.1016/j.tripleo.2004.07.013. View

18.

Eisen D . The clinical manifestations and treatment of oral lichen planus. Dermatol Clin. 2003; 21(1):79-89. DOI: 10.1016/s0733-8635(02)00067-0. View

19.

Jin X, Wang J, Zhu L, Wang L, Dan H, Zeng X . Association between -308 G/A polymorphism in TNF-α gene and lichen planus: a meta-analysis. J Dermatol Sci. 2012; 68(3):127-34. DOI: 10.1016/j.jdermsci.2012.09.003. View