Meta-analysis of the Relation Between Irritable Bowel Syndrome and Antibodies Against Endogenous Gonadotropin-releasing Hormone and Its Receptor

Overview

Journal Proc (Bayl Univ Med Cent)

Specialty General Medicine

Date 2022 Dec 29

PMID 36578611

Authors

Karam R Motawea

Joseph Varney

Mohamed Gamal

Kirellos Said Abbas

Fatma A Monib

Mhd Kutaiba Albuni

Elias Battikh

Bisher Sawaf

Lina Taha Khairy

Agyad Bakkour

Ali Hadi Hussein Muwaili

Fatima Abubaker Abdalla Abdelmajid

Eman Mohammed Sharif Ahmed

Dhuha Hadi Hussein Muwaili

Safaa M A Ahmed

Sarya Swed

Affiliations

Soon will be listed here.

Abstract

This meta-analysis assessed the association between gonadotropin hormone-releasing hormone (GnRH) antibodies and irritable bowel syndrome (IBS). We defined a search strategy and implemented it with PubMed, Ovid, Scopus, and Web of Science databases for English language publications. The data were evaluated for acceptability, and randomized controlled studies as well as case-control, cross-sectional, and cohort studies reporting the prevalence of GnRH antibodies in IBS patients were included. The total number of patients in the included studies was 1095: 270 patients in the IBS group and 825 patients in the control group. By comparing the IBS group and the control group, we found a statistically significant association between IBS and the increased prevalence of GnRH IgM antibodies (risk ratio = 2.29, 95% confidence interval = 1.58 to 3.31, < 0.0001). We also found a statistically significant association between IBS and increased prevalence of GnRH receptor IgM antibodies compared with controls (risk ratio = 3.80, 95% confidence interval = 1.72 to 8.38, = 0.001). The meta-analysis revealed a statistically significant association between IBS and increased prevalence of GnRH IgM and GnRH receptor IgM antibodies.

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