[Progress on the Design and Optimization of Antimicrobial Peptides]

Overview

Journal Sheng Wu Yi Xue Gong Cheng Xue Za Zhi

Specialty Biomedical Engineering

Date 2022 Dec 27

PMID 36575095

Authors

Ruonan Zhang

Di Wu

Yitian Gao

Affiliations

Soon will be listed here.

Abstract

Antimicrobial peptides (AMPs) are a class of peptides widely existing in nature with broad-spectrum antimicrobial activity. It is considered as a new alternative to traditional antibiotics because of its unique mechanism of antimicrobial activity. The development and application of natural AMPs are limited due to their drawbacks such as low antimicrobial activity and unstable metabolism. Therefore, the design and optimization of derived peptides based on natural antimicrobial peptides have become recent research hotspots. In this paper, we focus on ribosomal AMPs and summarize the design and optimization strategies of some related derived peptides, which include reasonable primary structure modification, cyclization strategy and computer-aided strategy. We expect to provide ideas for the design and optimization of antimicrobial peptides and the development of anti-infective drugs through analysis and summary in this paper.

Citing Articles

Transcriptome analysis of Corvus splendens reveals a repertoire of antimicrobial peptides.

Kannoth S, Ali N, Prasanth G, Arvind K, Mohany M, Hembrom P Sci Rep. 2023; 13(1):18728.

PMID: 37907616 PMC: 10618271. DOI: 10.1038/s41598-023-45875-w.

The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances.

Li H, Niu J, Wang X, Niu M, Liao C Pharmaceutics. 2023; 15(9).

PMID: 37765247 PMC: 10535326. DOI: 10.3390/pharmaceutics15092278.

[Near-infrared excited graphene oxide/silver nitrate/chitosan coating for improving antibacterial properties of titanium implants].

Wang Y, Xu Y, Zhang X, Liu J, Han J, Zhu S Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023; 37(8):937-944.

PMID: 37586792 PMC: 10435336. DOI: 10.7507/1002-1892.202303041.

References

Koehbach J, Craik D . The Vast Structural Diversity of Antimicrobial Peptides. Trends Pharmacol Sci. 2019; 40(7):517-528. DOI: 10.1016/j.tips.2019.04.012. View

Kim H, Jang J, Kim S, Cho J . Development of a novel hybrid antimicrobial peptide for targeted killing of Pseudomonas aeruginosa. Eur J Med Chem. 2019; 185:111814. DOI: 10.1016/j.ejmech.2019.111814. View

Di Bonaventura I, Jin X, Visini R, Probst D, Javor S, Gan B . Chemical space guided discovery of antimicrobial bridged bicyclic peptides against and its biofilms. Chem Sci. 2017; 8(10):6784-6798. PMC: 5643981. DOI: 10.1039/c7sc01314k. View

Ramazi S, Mohammadi N, Allahverdi A, Khalili E, Abdolmaleki P . A review on antimicrobial peptides databases and the computational tools. Database (Oxford). 2022; 2022. PMC: 9216472. DOI: 10.1093/database/baac011. View

Agouridas V, El Mahdi O, Diemer V, Cargoet M, Monbaliu J, Melnyk O . Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations. Chem Rev. 2019; 119(12):7328-7443. DOI: 10.1021/acs.chemrev.8b00712. View

Zhu X, Ma Z, Wang J, Chou S, Shan A . Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide. PLoS One. 2014; 9(12):e114605. PMC: 4262413. DOI: 10.1371/journal.pone.0114605. View

Koh J, Lin S, Beuerman R, Liu S . Recent advances in synthetic lipopeptides as anti-microbial agents: designs and synthetic approaches. Amino Acids. 2017; 49(10):1653-1677. DOI: 10.1007/s00726-017-2476-4. View

Sanner M, Dieguez L, Forli S, Lis E . Improving Docking Power for Short Peptides Using Random Forest. J Chem Inf Model. 2021; 61(6):3074-3090. PMC: 8543977. DOI: 10.1021/acs.jcim.1c00573. View

Hilpert K, Volkmer-Engert R, Walter T, Hancock R . High-throughput generation of small antibacterial peptides with improved activity. Nat Biotechnol. 2005; 23(8):1008-12. DOI: 10.1038/nbt1113. View

10.

Liu L, Zhao L, Liu L, Yue S, Wang J, Cao Z . Influence of Different Aromatic Hydrophobic Residues on the Antimicrobial Activity and Membrane Selectivity of BRBR-NH Tetrapeptide. Langmuir. 2020; 36(50):15331-15342. DOI: 10.1021/acs.langmuir.0c02777. View

11.

Di Bonaventura I, Baeriswyl S, Capecchi A, Gan B, Jin X, Siriwardena T . An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria. Chem Commun (Camb). 2018; 54(40):5130-5133. DOI: 10.1039/c8cc02412j. View

12.

Yadav V, Misra R . A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics. Biochimie. 2021; 191:126-139. DOI: 10.1016/j.biochi.2021.09.001. View

13.

Ting D, Beuerman R, Dua H, Lakshminarayanan R, Mohammed I . Strategies in Translating the Therapeutic Potentials of Host Defense Peptides. Front Immunol. 2020; 11:983. PMC: 7256188. DOI: 10.3389/fimmu.2020.00983. View

14.

Heinis C, Rutherford T, Freund S, Winter G . Phage-encoded combinatorial chemical libraries based on bicyclic peptides. Nat Chem Biol. 2009; 5(7):502-7. DOI: 10.1038/nchembio.184. View

15.

Salvagni E, Garcia C, Manresa A, Muller-Sanchez C, Reina M, Rodriguez-Abreu C . Short and ultrashort antimicrobial peptides anchored onto soft commercial contact lenses inhibit bacterial adhesion. Colloids Surf B Biointerfaces. 2020; 196:111283. DOI: 10.1016/j.colsurfb.2020.111283. View

16.

Choudhury A, Islam S, Ghidey M, Kearney C . Repurposing a drug targeting peptide for targeting antimicrobial peptides against Staphylococcus. Biotechnol Lett. 2019; 42(2):287-294. DOI: 10.1007/s10529-019-02779-y. View

17.

Kamysz E, Sikorska E, Jaskiewicz M, Bauer M, Neubauer D, Bartoszewska S . Lipidated Analogs of the LL-37-Derived Peptide Fragment KR12-Structural Analysis, Surface-Active Properties and Antimicrobial Activity. Int J Mol Sci. 2020; 21(3). PMC: 7036753. DOI: 10.3390/ijms21030887. View

18.

Dwivedi R, Aggarwal P, Bhavesh N, Kaur K . Design of therapeutically improved analogue of the antimicrobial peptide, indolicidin, using a glycosylation strategy. Amino Acids. 2019; 51(10-12):1443-1460. DOI: 10.1007/s00726-019-02779-2. View

19.

Zou P, Chen W, Sun T, Gao Y, Li L, Wang H . Recent advances: peptides and self-assembled peptide-nanosystems for antimicrobial therapy and diagnosis. Biomater Sci. 2020; 8(18):4975-4996. DOI: 10.1039/d0bm00789g. View

20.

Li H, Hu Y, Pu Q, He T, Zhang Q, Wu W . Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides. J Med Chem. 2020; 63(8):4081-4089. DOI: 10.1021/acs.jmedchem.9b02025. View