Alteration of Hepatic Phospholipids in Rats and Mice by Feeding Di-(2-ethylhexyl)adipate and Di-(2-ethylhexyl)phthalate

Overview

Journal Lipids

Specialty Biochemistry

Date 1987 Aug 1

PMID 3657395

Citations 1

Authors

T Yanagita

M Satoh

H Nomura

N Enomoto

M Sugano

Affiliations

Soon will be listed here.

Abstract

Effects of di-(2-ethylhexyl)adipate (DOA) and di-(2-ethylhexyl)phthalate (DEHP), plasticizers for polyvinylchloride products, on concentrations and compositions of hepatic phospholipids were studied in rats. When administered to rats at a 2% level for 2 wk, both DOA and DEHP caused a hepatomegaly, an increase in hepatic phospholipids and a decrease an increase in hepatic phospholipids and a decrease in the ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE). In the comparable study with mice, the alkyl moiety of DOA was found to be responsible for these alterations. DOA and DEHP specifically altered fatty acid compositions of PC and PE: there was an increase in oleic and palmitic acids and a decrease in stearic and docosahexaenoic acids in PC and an increase in arachidonic acid at the expense of docosahexaenoic acid in PE. In addition, DOA caused an increase in the trienoic and tetraenoic molecular species in PC and an increase in the 1-palmitoyl-2-arachidonyl (16:0@20:4) species in PE. Thus, the effects of DOA on the lipid dynamics resembled those observed with DEHP, although the magnitude was slightly moderated.

Citing Articles

Prenatal maternal phthalate exposures and child lipid and adipokine levels at age six: A study from the PROGRESS cohort of Mexico City.

Kupsco A, Wu H, Calafat A, Kioumourtzoglou M, Tamayo-Ortiz M, Pantic I Environ Res. 2020; 192:110341.

PMID: 33068586 PMC: 7736226. DOI: 10.1016/j.envres.2020.110341.

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