Effects of Triton WR 1339 and Orotic Acid on Lipid Metabolism in Rats

Overview

Journal Lipids

Specialty Biochemistry

Date 1987 Aug 1

PMID 3657394

Citations 1

Authors

N Takeuchi

M Murase

Y Nomura

H Takase

K Uchida

Affiliations

Soon will be listed here.

Abstract

In order to investigate the effect of hepatic cholesterol flux on biliary bile acids, Triton WR 1339 and orotic acid were administered to rats, and the biliary cholesterol, phospholipids and bile acids were analyzed together with serum lipoproteins and hepatic lipids. Triton, which raised serum very low density lipoprotein and lipid levels and decreased serum high density lipoprotein liver lipid levels, increase the biliary cholic acid group/chenodeoxycholic acid group ratio (CA/CDCA) in the bile without affecting the total amount of bile acids and the other biliary lipids. Orotic acid, which decreased serum lipid and lipoprotein concentrations and increased liver lipid levels, increased the biliary excretion of cholesterol and phospholipids, but produced no significant change in the total amount of bile acids and in the CA/CDCA ratio in bile.

Citing Articles

Bile acid metabolism in young-old parabiotic rats.

Uchida K, Takase H, Nomura Y, Satoh T, Igimi H, Takeuchi N Lipids. 1997; 32(4):383-90.

PMID: 9113626 DOI: 10.1007/s11745-997-0049-5.

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