Hydrogel Derived from Glucomannan-Chitosan to Improve the Survival of FNCC 0051 in Simulated Gastrointestinal Fluid

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2022 Dec 26

PMID 36571080

Authors

Veriani Aprilia

Agnes Murdiati

Pudji Hastuti

Eni Harmayani

Affiliations

Soon will be listed here.

Abstract

The probiotic encapsulating hydrogel derived from porang () glucomannan and chitosan was investigated with regard to its encapsulation efficiency, physical properties, prebiotic activity, and survival under simulated gastrointestinal conditions. The hydrogel's encapsulation efficiency was improved by varying the number of the FNCC 0051, which also served to increase the diameter (2-3 mm), polydispersity index (1.23-1.65), positive zeta potential, whiteness, and brightness of the hydrogel. Moreover, the hydrogel's prebiotic activity score was higher than that of inulin after 24 h of incubation, reflecting its role as a cell encapsulant, particularly when it comes to maintaining cells during exposure to simulated gastrointestinal fluid. The cell viability increased from 86% to 100% when immersed in intestinal juice, which is comparable to the increase achieved using alginate and konjac glucomannan hydrogels. Future animal studies are required to determine the cell viability in actual gastrointestinal conditions and assess the health effects of the hydrogel.

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