Plant Metabolite Diosmin As the Therapeutic Agent in Human Diseases

Overview

Journal Curr Res Pharmacol Drug Discov

Date 2022 Dec 26

PMID 36568270

Authors

Saad Mustafa

Mahmood Akbar

Mohammad Aasif Khan

Kumari Sunita

Shabana Parveen

Jogendra Singh Pawar

Sheersh Massey

Nupur Rani Agarwal

Syed Akhtar Husain

Affiliations

Soon will be listed here.

Abstract

Plant-derived flavonoids have been the focus of research for many years mainly in the last decade owing to their therapeutic properties. So far, about 4000 flavonoids have been identified from plants and diosmin (a flavone glycoside) is one of them. Online databases, previous studies, and reviews have been used to gather information on anti-oxidant, immunomodulatory, anti-cancer, anti-parasitic, and anti-microbialproperties of diosmin. Effects of diosmin in combination with other flavonoids have been reviewed thoroughly and its administrative routes are also summarized. Additionally, we studied the effect of diosmin on critical protein networks. It exhibits therapeutic effects in diabetes and its associated complications such as neuropathy and dyslipidemia. Combination of diosmin with hesperidin is found to be very effective in the treatment of chronic venous insufficiency and haemorrhoids. Diosmin is an exquisite therapeutic agent alone as well as in combination with other flavonoids.

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