High-grade Vaginal Intraepithelial Neoplasia and Recurrence Risk: Analysis of an Italian Regional Referral Center Series

Overview

Journal Arch Gynecol Obstet

Specialty Gynecology & Obstetrics

Date 2022 Dec 23

PMID 36564638

Authors

Ermelinda Monti

Giada Libutti

Eugenia Di Loreto

Veronica Boero

Giussy Barbara

Maria Iorio

Giulia Emily Cetera

Sonia Cipriani

Fabio Parazzini

Affiliations

Soon will be listed here.

Abstract

Purpose: The main aim of this study was to investigate the long-term risk of disease recurrence in women treated for high-grade vaginal intraepithelial neoplasia (HG-VaIN).

Methods: We conducted a retrospective analysis on a cohort of 82 women diagnosed with HG-VaIN between 2010 and 2021 at the "Regional Referral Center for Prevention, Diagnosis and Treatment of HPV-related Genital Disorders", Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. All women underwent either ablative treatment (CO laser ablation or electrocoagulation) or cold-knife excision.

Results: In our series, the recurrence rate following treatment was 17%. The 5-year cumulative probability of recurrence was 30.4% and the median time to recurrence was 15.5 months. None of the patients progressed to invasive vaginal cancer during follow-up. A concomitant cervical or vulvar intraepithelial lesion was significatively associated with an increased risk of recurrence (p = 0.006).

Conclusions: The results of our study suggest that women with HG-VaIN are at high risk of developing disease recurrence after treatment, especially patients with a concomitant cervical or vulvar intraepithelial lesion. In these women strict monitoring is mandatory to obtain an early identification of recurrence.

Citing Articles

Comprehensive evaluation of vaginal intraepithelial neoplasia development after hysterectomy: insights into diagnosis and treatment strategies.

Wei J, Wu Y Arch Gynecol Obstet. 2024; 310(1):1-10.

PMID: 38743076 PMC: 11168985. DOI: 10.1007/s00404-024-07530-1.

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