Vaccination Against Bacterial Mastitis in Sheep

Overview

Journal Vaccines (Basel)

Date 2022 Dec 23

PMID 36560497

Authors

Natalia G C Vasileiou

Daphne T Lianou

Charalambia K Michael

George C Fthenakis

Vasia S Mavrogianni

Affiliations

Soon will be listed here.

Abstract

The objective of this review is to discuss the application of vaccination for the prevention of bacterial mastitis in ewes, performed within the frame of health management schemes in sheep flocks. Mastitis is a multi-faceted infection, caused most often by staphylococci; hence, special emphasis is given to staphylococcal mastitis, also given that most relevant studies refer to vaccinations against that infection. Studies regarding various vaccines have been performed; most studies refer to vaccination by using a vaccine making use of cell-free surface polysaccharides in various vehicles, bacterial unbound cells or bacterial cells embedded in their biofilm matrix. Vaccination against mastitis should be better performed during the final stage of pregnancy to allow protection of ewes from lambing and should be considered as one of many control measures for the prevention of the disease. The expected benefits of mastitis vaccination in sheep flocks include the following: (a) reduced incidence risk of clinical and subclinical mastitis, (b) reduced somatic cell counts, optimum chemical composition, absence of staphylococci in milk, (c) increased milk production, (d) reduced dissemination of mastitis-causing pathogens and (e) reduction of antibiotic use in flocks.

Citing Articles

An Investigation of Virulence Genes of in Autologous Vaccines Against Sheep Mastitis.

Sezzi E, Fanelli R, Gobbi D, Scandurra P, Mannucci V, Usai I Animals (Basel). 2024; 14(22).

PMID: 39595225 PMC: 11591023. DOI: 10.3390/ani14223172.

The Use of Machine Learning to Predict Prevalence of Subclinical Mastitis in Dairy Sheep Farms.

Kiouvrekis Y, Vasileiou N, Katsarou E, Lianou D, Michael C, Zikas S Animals (Basel). 2024; 14(16).

PMID: 39199829 PMC: 11350869. DOI: 10.3390/ani14162295.

Production of recombinant proteins including the B-cell epitopes of autolysin A of Staphylococcus aureus isolated from clinical sheep mastitis and their potential for vaccine development.

Azara E, Foddai A, Longheu C, Addis M, Tola S Vet Res Commun. 2023; 47(3):1665-1674.

PMID: 37074614 PMC: 10113713. DOI: 10.1007/s11259-023-10121-1.

References

Hine B, Hunt P, Beasley A, Windon R, Glover S, Colditz I . Selective transport of IgE into ovine mammary secretions. Res Vet Sci. 2010; 89(2):184-90. DOI: 10.1016/j.rvsc.2010.02.010. View

Watson D . Vaccination against experimental staphylococcal mastitis in ewes. Res Vet Sci. 1988; 45(1):16-21. View

Azara E, Longheu C, Sanna G, Tola S . Biofilm formation and virulence factor analysis of Staphylococcus aureus isolates collected from ovine mastitis. J Appl Microbiol. 2017; 123(2):372-379. DOI: 10.1111/jam.13502. View

Prenafeta A, March R, Foix A, Casals I, Costa L . Study of the humoral immunological response after vaccination with a Staphylococcus aureus biofilm-embedded bacterin in dairy cows: possible role of the exopolysaccharide specific antibody production in the protection from Staphylococcus aureus.... Vet Immunol Immunopathol. 2009; 134(3-4):208-17. DOI: 10.1016/j.vetimm.2009.09.020. View

Craven N, Williams M . Defences of the bovine mammary gland against infection and prospects for their enhancement. Vet Immunol Immunopathol. 1985; 10(1):71-127. DOI: 10.1016/0165-2427(85)90039-x. View

Bergonier D, de Cremoux R, Rupp R, Lagriffoul G, Berthelot X . Mastitis of dairy small ruminants. Vet Res. 2003; 34(5):689-716. DOI: 10.1051/vetres:2003030. View

Tassi R, Schiavo M, Filipe J, Todd H, Ewing D, Ballingall K . Intramammary Immunisation Provides Short Term Protection Against Mastitis in Sheep. Front Vet Sci. 2021; 8:659803. PMC: 8222732. DOI: 10.3389/fvets.2021.659803. View

Lianou D, Michael C, Petinaki E, Mavrogianni V, Fthenakis G . Administration of Vaccines in Dairy Sheep and Goat Farms: Patterns of Vaccination, Associations with Health and Production Parameters, Predictors. Vaccines (Basel). 2022; 10(9). PMC: 9502793. DOI: 10.3390/vaccines10091372. View

Kabay M, Ellis T . Intraperitoneal inoculation of ewes with an autogenous vaccine to prevent mastitis due to Pasteurella haemolytica. Aust Vet J. 1989; 66(10):342-3. DOI: 10.1111/j.1751-0813.1989.tb09726.x. View

10.

Kyriakis C . Tomorrow's vector vaccines for small ruminants. Vet Microbiol. 2015; 181(1-2):47-52. DOI: 10.1016/j.vetmic.2015.08.003. View

11.

Katsafadou A, Politis A, Mavrogianni V, Barbagianni M, Vasileiou N, Fthenakis G . Mammary Defences and Immunity against Mastitis in Sheep. Animals (Basel). 2019; 9(10). PMC: 6826578. DOI: 10.3390/ani9100726. View

12.

Vasileiou N, Chatzopoulos D, Cripps P, Ioannidi K, Gougoulis D, Chouzouris T . Evaluation of efficacy of a biofilm-embedded bacteria-based vaccine against staphylococcal mastitis in sheep-A randomized, placebo-controlled field study. J Dairy Sci. 2019; 102(10):9328-9344. DOI: 10.3168/jds.2019-16287. View

13.

Gelasakis A, Mavrogianni V, Petridis I, Vasileiou N, Fthenakis G . Mastitis in sheep--The last 10 years and the future of research. Vet Microbiol. 2015; 181(1-2):136-46. DOI: 10.1016/j.vetmic.2015.07.009. View

14.

Mavrogianni V, Cripps P, Fthenakis G . Bacterial flora and risk of infection of the ovine teat duct and mammary gland throughout lactation. Prev Vet Med. 2007; 79(2-4):163-73. DOI: 10.1016/j.prevetmed.2006.11.014. View

15.

Barrio M, Rainard P, Poutrel B . Milk complement and the opsonophagocytosis and killing of Staphylococcus aureus mastitis isolates by bovine neutrophils. Microb Pathog. 2003; 34(1):1-9. DOI: 10.1016/s0882-4010(02)00186-9. View

16.

Cunnion K, Lee J, Frank M . Capsule production and growth phase influence binding of complement to Staphylococcus aureus. Infect Immun. 2001; 69(11):6796-803. PMC: 100057. DOI: 10.1128/IAI.69.11.6796-6803.2001. View

17.

Koop G, Rietman J, Pieterse M . Staphylococcus aureus mastitis in Texel sheep associated with suckling twins. Vet Rec. 2011; 167(22):868-9. DOI: 10.1136/vr.c3375. View

18.

Ostensson K, Lun S . Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin. Acta Vet Scand. 2008; 50:26. PMC: 2483282. DOI: 10.1186/1751-0147-50-26. View

19.

Vasileiou N, Cripps P, Ioannidi K, Chatzopoulos D, Gougoulis D, Sarrou S . Extensive countrywide field investigation of subclinical mastitis in sheep in Greece. J Dairy Sci. 2018; 101(8):7297-7310. DOI: 10.3168/jds.2017-14075. View

20.

Rainard P . The complement in milk and defense of the bovine mammary gland against infections. Vet Res. 2003; 34(5):647-70. DOI: 10.1051/vetres:2003025. View