PAMAM-Calix-Dendrimers: Second Generation Synthesis, Fluorescent Properties and Catecholamines Binding

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2022 Dec 23

PMID 36559243

Authors

Olga Mostovaya

Igor Shiabiev

Dmitry Pysin

Alesia Stanavaya

Viktar Abashkin

Dzmitry Shcharbin

Pavel Padnya

Ivan Stoikov

Affiliations

Soon will be listed here.

Abstract

A convenient method for the synthesis of the second generation of PAMAM dendrimers based on a -butylthiacalix[4]arene core in , and conformations was developed. Unusual fluorescence of the obtained PAMAM-calix-dendrimers has been found and explained. The binding ability of the synthesized dendrimers toward catecholamines (dopamine, -adrenaline and -noradrenaline) was shown by UV-Vis, fluorescence, 1D and 2D NMR spectroscopy and the binding constants (logK 3.85-4.74) calculated. As was shown, the PAMAM-calix-dendrimers bind catecholamines by the internal cavities. All the studied hormones were most efficiently bound by the dendrimers bearing a macrocyclic core in conformation. The size of the formed supramolecular systems of dendrimer/catecholamine was established by the DLS method. A decrease in hemolytic activity of the PAMAM-calix-dendrimers with an increase in the generation number of a dendrimer was shown for the dendrimers with a core in conformation. The prospects for the use of the synthesized dendrimers with the macrocyclic core as drug delivery agents were discussed.

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