-Hydroxybenzoic Acid Ameliorates Colitis by Improving the Mucosal Barrier in a Gut Microbiota-Dependent Manner

Overview

Journal Nutrients

Date 2022 Dec 23

PMID 36558542

Authors

Xue Han

Miaomiao Li

Lijun Sun

Xinjuan Liu

Yue Yin

Jianyu Hao

Weizhen Zhang

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease characterized by intestinal inflammatory cell infiltration and intestinal mucosal damage. The mechanism by which diet contributes to the pathogenesis of IBD remains largely unknown. In this study, we explored the therapeutic effect of -hydroxybenzoic acid (HA), a phenolic acid mainly derived from dietary polyphenols in the gut, on DSS-induced colitis. HA intervention effectively relieved the dextran sulfate sodium salt (DSS)-induced colitis, reduced inflammation, and enhanced mucosal barrier function, as evidenced by an increment of goblet cell numbers and MUC2. These effects were largely dependent on the gut microbiota (GM), as antibiotics treatment substantially attenuated the improvement of colitis by HA. On the other hand, transplantation of GM from colitis mice treated with HA significantly reduced the colitis induced by DSS. Our study demonstrates that HA ameliorates DSS-induced colitis by improving the mucosal barrier in a GM-dependent manner. This study provides new dietary choices for the prevention and treatment of IBD.

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References

Zhang Y, Wu S, Qin Y, Liu J, Liu J, Wang Q . Interaction of phenolic acids and their derivatives with human serum albumin: Structure-affinity relationships and effects on antioxidant activity. Food Chem. 2017; 240:1072-1080. DOI: 10.1016/j.foodchem.2017.07.100. View

Lavelle A, Sokol H . Gut microbiota-derived metabolites as key actors in inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2020; 17(4):223-237. DOI: 10.1038/s41575-019-0258-z. View

Islam M, Murata T, Fujisawa M, Nagasaka R, Ushio H, Bari A . Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice. Br J Pharmacol. 2008; 154(4):812-24. PMC: 2439859. DOI: 10.1038/bjp.2008.137. View

Dey P . Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions. Pharmacol Res. 2019; 147:104367. DOI: 10.1016/j.phrs.2019.104367. View

Dey P, Ray Chaudhuri S . The opportunistic nature of gut commensal microbiota. Crit Rev Microbiol. 2022; 49(6):739-763. DOI: 10.1080/1040841X.2022.2133987. View

Mak W, Zhao M, Ng S, Burisch J . The epidemiology of inflammatory bowel disease: East meets west. J Gastroenterol Hepatol. 2019; 35(3):380-389. DOI: 10.1111/jgh.14872. View

Khadem S, Marles R . Monocyclic phenolic acids; hydroxy- and polyhydroxybenzoic acids: occurrence and recent bioactivity studies. Molecules. 2010; 15(11):7985-8005. PMC: 6259451. DOI: 10.3390/molecules15117985. View

Kaplan G . The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol. 2015; 12(12):720-7. DOI: 10.1038/nrgastro.2015.150. View

Zamora-Ros R, Rothwell J, Scalbert A, Knaze V, Romieu I, Slimani N . Dietary intakes and food sources of phenolic acids in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Nutr. 2013; 110(8):1500-11. DOI: 10.1017/S0007114513000688. View

10.

Panpetch W, Hiengrach P, Nilgate S, Tumwasorn S, Somboonna N, Wilantho A . Additional administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by L34. Gut Microbes. 2019; 11(3):465-480. PMC: 7527076. DOI: 10.1080/19490976.2019.1662712. View

11.

Khalili H, Chan S, Lochhead P, Ananthakrishnan A, Hart A, Chan A . The role of diet in the aetiopathogenesis of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2018; 15(9):525-535. PMC: 6397648. DOI: 10.1038/s41575-018-0022-9. View

12.

Dey P, Ray Chaudhuri S, Efferth T, Pal S . The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist - from fundamentals to future challenges. Free Radic Biol Med. 2021; 176:265-285. DOI: 10.1016/j.freeradbiomed.2021.09.026. View

13.

Qian B, Wang C, Zeng Z, Ren Y, Li D, Song J . Ameliorative Effect of Sinapic Acid on Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in Kunming (KM) Mice. Oxid Med Cell Longev. 2020; 2020:8393504. PMC: 7719534. DOI: 10.1155/2020/8393504. View

14.

Li D, Feng Y, Tian M, Ji J, Hu X, Chen F . Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation. Microbiome. 2021; 9(1):83. PMC: 8022418. DOI: 10.1186/s40168-021-01028-7. View

15.

Lan H, Zhang L, He W, Li W, Zeng Z, Qian B . Sinapic Acid Alleviated Inflammation-Induced Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide- (LPS-) Treated Caco-2 Cells. Mediators Inflamm. 2021; 2021:5514075. PMC: 8443358. DOI: 10.1155/2021/5514075. View

16.

Lee Y, Shin D, Lim B . Chlorogenic Acid Improves Symptoms of Inflammatory Bowel Disease in Interleukin-10 Knockout Mice. J Med Food. 2020; 23(10):1043-1053. DOI: 10.1089/jmf.2019.4621. View

17.

Gao W, Wang C, Yu L, Sheng T, Wu Z, Wang X . Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway. Biomed Res Int. 2019; 2019:6769789. PMC: 6500688. DOI: 10.1155/2019/6769789. View

18.

Svolos V, Hansen R, Nichols B, Quince C, Ijaz U, Papadopoulou R . Treatment of Active Crohn's Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral Nutrition. Gastroenterology. 2018; 156(5):1354-1367.e6. DOI: 10.1053/j.gastro.2018.12.002. View

19.

Lee J . Anti-inflammatory effects of sinapic acid on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice. Arch Pharm Res. 2018; 41(2):243-250. DOI: 10.1007/s12272-018-1006-6. View

20.

Dey P . Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases. Pharmacol Res. 2020; 161:105135. DOI: 10.1016/j.phrs.2020.105135. View