Potential Role of Bioactive Proteins and Peptides Derived from Legumes Towards Metabolic Syndrome

Overview

Journal Nutrients

Date 2022 Dec 23

PMID 36558429

Authors

Marta Garces-Rimon

Diego Morales

Marta Miguel-Castro

Affiliations

Soon will be listed here.

Abstract

Legumes have been widely consumed and used to isolate bioactive compounds, mainly proteins. The aim of this study was to review the beneficial actions of different legumes proteins and peptides updating the main findings that correlate legumes consumption and the effects on non-transmissible chronic diseases, specifically metabolic syndrome. An exhaustive revision of five relevant bioactivities (antioxidant, anti-inflammatory, antihypertensive, hypocholesterolemic -all of them linked to metabolic syndrome- and antitumoral) of proteins and peptides from legumes focused on isolation and purification, enzymatic hydrolysis and in vitro gastrointestinal digestion was carried out. The promising potential of bioactive hydrolysates and peptides from pulses has been demonstrated by in vitro tests. However, only a few studies validated these biological activities using animal models. No clinical trials have been carried out yet; so further research is required to elucidate their effective health implications.

Citing Articles

Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and Challenges.

Chen Y, Yang J, Rao Q, Wang C, Chen X, Zhang Y Foods. 2023; 12(24).

PMID: 38137270 PMC: 10742721. DOI: 10.3390/foods12244465.

Recent Trends in Cereal- and Legume-Based Protein-Mineral Complexes: Formulation Methods, Toxicity, and Food Applications.

Jindal A, Patil N, Bains A, Sridhar K, Inbaraj B, Tripathi M Foods. 2023; 12(21).

PMID: 37959017 PMC: 10649166. DOI: 10.3390/foods12213898.

Recent Advances in In Vitro and In Vivo Studies of Antioxidant, ACE-Inhibitory and Anti-Inflammatory Peptides from Legume Protein Hydrolysates.

Tawalbeh D, Al-Udatt M, Ahmad W, Ahmad F, Sarbon N Molecules. 2023; 28(6).

PMID: 36985395 PMC: 10056053. DOI: 10.3390/molecules28062423.

References

Price S, Pangloli P, Krishnan H, Dia V . Kunitz trypsin inhibitor in addition to Bowman-Birk inhibitor influence stability of lunasin against pepsin-pancreatin hydrolysis. Food Res Int. 2017; 90:205-215. DOI: 10.1016/j.foodres.2016.10.051. View

Ajibola C, Fashakin J, Fagbemi T, Aluko R . Effect of peptide size on antioxidant properties of African yam bean seed (Sphenostylis stenocarpa) protein hydrolysate fractions. Int J Mol Sci. 2011; 12(10):6685-702. PMC: 3211003. DOI: 10.3390/ijms12106685. View

Ndiaye F, Vuong T, Duarte J, Aluko R, Matar C . Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds. Eur J Nutr. 2011; 51(1):29-37. DOI: 10.1007/s00394-011-0186-3. View

Li G, Wan J, Le G, Shi Y . Novel angiotensin I-converting enzyme inhibitory peptides isolated from Alcalase hydrolysate of mung bean protein. J Pept Sci. 2006; 12(8):509-14. DOI: 10.1002/psc.758. View

Hasler C . The cardiovascular effects of soy products. J Cardiovasc Nurs. 2003; 16(4):50-63; quiz 75-6. DOI: 10.1097/00005082-200207000-00006. View

Leite J, Assreuy A, Mota M, de Souza Ferreira Bringel P, E Lacerda R, de Morais Gomes V . Antinociceptive and anti-inflammatory effects of a lectin-like substance from Clitoria fairchildiana R. Howard seeds. Molecules. 2012; 17(3):3277-90. PMC: 6268884. DOI: 10.3390/molecules17033277. View

Navarro Del Hierro J, Herrera T, Garcia-Risco M, Fornari T, Reglero G, Martin D . Ultrasound-assisted extraction and bioaccessibility of saponins from edible seeds: quinoa, lentil, fenugreek, soybean and lupin. Food Res Int. 2018; 109:440-447. DOI: 10.1016/j.foodres.2018.04.058. View

Vernaza M, Dia V, Gonzalez de Mejia E, Chang Y . Antioxidant and antiinflammatory properties of germinated and hydrolysed Brazilian soybean flours. Food Chem. 2013; 134(4):2217-25. DOI: 10.1016/j.foodchem.2012.04.037. View

Sirtori C, Lovati M, Manzoni C, Castiglioni S, Duranti M, Magni C . Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells. J Nutr. 2004; 134(1):18-23. DOI: 10.1093/jn/134.1.18. View

10.

Xue Z, Hou X, Yu W, Wen H, Zhang Q, Li D . Lipid metabolism potential and mechanism of CPe-III from chickpea (Cicer arietinum L.). Food Res Int. 2018; 104:126-133. DOI: 10.1016/j.foodres.2017.03.016. View

11.

Lule V, Garg S, Pophaly S, Hitesh , Tomar S . "Potential health benefits of lunasin: a multifaceted soy-derived bioactive peptide". J Food Sci. 2015; 80(3):R485-94. DOI: 10.1111/1750-3841.12786. View

12.

Ferreira E, Silva M, Demonte A, Augusto Neves V . Soy β-conglycinin (7S globulin) reduces plasma and liver cholesterol in rats fed hypercholesterolemic diet. J Med Food. 2010; 14(1-2):94-100. DOI: 10.1089/jmf.2009.0204. View

13.

Garcia-Gasca T, Garcia-Cruz M, Hernandez-Rivera E, Lopez-Matinez J, Castaneda-Cuevas A, Yllescas-Gasca L . Effects of Tepary bean (Phaseolus acutifolius) protease inhibitor and semipure lectin fractions on cancer cells. Nutr Cancer. 2012; 64(8):1269-78. PMC: 3856472. DOI: 10.1080/01635581.2012.722246. View

14.

Sarmadi B, Ismail A . Antioxidative peptides from food proteins: a review. Peptides. 2010; 31(10):1949-56. DOI: 10.1016/j.peptides.2010.06.020. View

15.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

16.

Jiang Y, Zhao D, Sun J, Luo X, Li H, Sun X . Analysis of antioxidant effect of two tripeptides isolated from fermented grains (Jiupei) and the antioxidative interaction with 4-methylguaiacol, 4-ethylguaiacol, and vanillin. Food Sci Nutr. 2019; 7(7):2391-2403. PMC: 6657717. DOI: 10.1002/fsn3.1100. View

17.

Mojica L, Luna-Vital D, Gonzalez de Mejia E . Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress. J Sci Food Agric. 2016; 97(8):2401-2410. DOI: 10.1002/jsfa.8053. View

18.

Chakrabarti S, Guha S, Majumder K . Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. Nutrients. 2018; 10(11). PMC: 6265732. DOI: 10.3390/nu10111738. View

19.

Gil-Ramirez A, Morales D, Soler-Rivas C . Molecular actions of hypocholesterolaemic compounds from edible mushrooms. Food Funct. 2017; 9(1):53-69. DOI: 10.1039/c7fo00835j. View

20.

Saito T, Sato H, Virgona N, Hagiwara H, Kashiwagi K, Suzuki K . Negative growth control of osteosarcoma cell by Bowman-Birk protease inhibitor from soybean; involvement of connexin 43. Cancer Lett. 2007; 253(2):249-57. DOI: 10.1016/j.canlet.2007.01.021. View