The Optimal Management of Infections

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Dec 23

PMID 36557641

Authors

Ramona Gabriela Ursu

Ionut Luchian

Costin Damian

Elena Porumb-Andrese

Roxana Gabriela Cobzaru

Giorgio Nichitean

Carmen Ripa

Diana Costin

Darius Sandu

Ioana-Maria Andrioaie

Luminita Smaranda Iancu

Affiliations

Soon will be listed here.

Abstract

is one of the most frequent etiologic agents of STDs (sexually transmitted diseases). Untreated asymptomatic gonococcal infection in women can lead to spreading of the infection in the sexually active population and could lead to late consequences, such as sterility or ectopic pregnancies. One important issue about is its increasing resistance to antibiotics. This paper summarized the newest molecular antimicrobial resistance (AMR) detection assays for connected with the latest therapeutic antimicrobials and gonococcal vaccine candidates. The assays used to detect AMR varied from the classical minimal inhibitory concentration (MIC) detection to whole-genome sequencing. New drugs against multi drug resistant (MDR) have been proposed and were evaluated in vivo and in vitro as being efficient in decreasing the burden. In addition, anti- vaccine candidates are being researched, which have been assessed by multiple techniques. With the efforts of many researchers who are studying the detection of antimicrobial resistance in this bacterium and identifying new drugs and new vaccine candidates against it, there is hope in reducing the gonorrhea burden worldwide.

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