Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Dec 23

PMID 36555733

Authors

Heinig Leo

Markus Kipp

Affiliations

Soon will be listed here.

Abstract

Remyelination therapies, which are currently under development, have a great potential to delay, prevent or even reverse disability in multiple sclerosis patients. Several models are available to study the effectiveness of novel compounds in vivo, among which is the cuprizone model. This model is characterized by toxin-induced demyelination, followed by endogenous remyelination after cessation of the intoxication. Due to its high reproducibility and ease of use, this model enjoys high popularity among various research and industrial groups. In this review article, we will summarize recent findings using this model and discuss the potential of some of the identified compounds to promote remyelination in multiple sclerosis patients.

Citing Articles

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VEP Latency Delay Reflects Demyelination Beyond the Optic Nerve in the Cuprizone Model.

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How to Use the Cuprizone Model to Study De- and Remyelination.

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Pharmacological Effects of FTY720 and its Derivatives.

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