MicroRNAs: A Link Between Mammary Gland Development and Breast Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Dec 23

PMID 36555616

Authors

Diana Wu

Lilian U Thompson

Elena M Comelli

Affiliations

Soon will be listed here.

Abstract

Breast cancer is among the most common cancers in women, second to skin cancer. Mammary gland development can influence breast cancer development in later life. Processes such as proliferation, invasion, and migration during mammary gland development can often mirror processes found in breast cancer. MicroRNAs (miRNAs), small, non-coding RNAs, can repress post-transcriptional RNA expression and can regulate up to 80% of all genes. Expression of miRNAs play a key role in mammary gland development, and aberrant expression can initiate or promote breast cancer. Here, we review the role of miRNAs in mammary development and breast cancer, and potential parallel roles. A total of 32 miRNAs were found to be expressed in both mammary gland development and breast cancer. These miRNAs are involved in proliferation, metastasis, invasion, and apoptosis in both processes. Some miRNAs were found to have contradictory roles, possibly due to their ability to target many genes at once. Investigation of miRNAs and their role in mammary gland development may inform about their role in breast cancer. In particular, by studying miRNA in development, mechanisms and potential targets for breast cancer treatment may be elucidated.

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References

Xu Y, Qian C, Liu C, Fu Y, Zhu K, Niu Z . Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis. Contrast Media Mol Imaging. 2022; 2022:4657952. PMC: 9239777. DOI: 10.1155/2022/4657952. View

Martini S, Zuco V, Tortoreto M, Percio S, Campi E, El Bezawy R . miR-34a-Mediated Survivin Inhibition Improves the Antitumor Activity of Selinexor in Triple-Negative Breast Cancer. Pharmaceuticals (Basel). 2021; 14(6). PMC: 8227962. DOI: 10.3390/ph14060523. View

Soni M, Patel Y, Markoutsa E, Jie C, Liu S, Xu P . Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer. Mol Cancer Res. 2018; 16(9):1348-1360. PMC: 6843115. DOI: 10.1158/1541-7786.MCR-17-0634. View

Fang J, Huang C, Ke J, Li J, Zhang W, Xue H . lncRNA TTN-AS1 facilitates proliferation, invasion, and epithelial-mesenchymal transition of breast cancer cells by regulating miR-139-5p/ZEB1 axis. J Cell Biochem. 2020; 121(12):4772-4784. DOI: 10.1002/jcb.29700. View

Zhang J, Ke S, Zheng W, Zhu Z, Wu Y . Hsa_circ_0003645 Promotes Breast Cancer Progression by Regulating miR-139-3p/HMGB1 Axis. Onco Targets Ther. 2020; 13:10361-10372. PMC: 7568624. DOI: 10.2147/OTT.S265796. View

Han Y, Bi Y, Bi H, Diao C, Zhang G, Cheng K . miR-137 suppresses the invasion and procedure of EMT of human breast cancer cell line MCF-7 through targeting CtBP1. Hum Cell. 2015; 29(1):30-6. DOI: 10.1007/s13577-015-0124-4. View

Chu M, Zhao Y, Yu S, Hao Y, Zhang P, Feng Y . miR-15b negatively correlates with lipid metabolism in mammary epithelial cells. Am J Physiol Cell Physiol. 2017; 314(1):C43-C52. DOI: 10.1152/ajpcell.00115.2017. View

Harbeck N, Penault-Llorca F, Cortes J, Gnant M, Houssami N, Poortmans P . Breast cancer. Nat Rev Dis Primers. 2019; 5(1):66. DOI: 10.1038/s41572-019-0111-2. View

Boyd N, Martin L, Yaffe M, Minkin S . Mammographic density and breast cancer risk: current understanding and future prospects. Breast Cancer Res. 2011; 13(6):223. PMC: 3326547. DOI: 10.1186/bcr2942. View

10.

Shupp A, Neupane M, Agostini L, Ning G, Brody J, Bussard K . Stromal-Derived Extracellular Vesicles Suppress Proliferation of Bone Metastatic Cancer Cells Mediated by ERK2. Mol Cancer Res. 2021; 19(10):1763-1777. PMC: 8492519. DOI: 10.1158/1541-7786.MCR-20-0981. View

11.

Mansoori B, Duijf P, Mohammadi A, Safarzadeh E, Ditzel H, Gjerstorff M . MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sci. 2021; 276:119431. DOI: 10.1016/j.lfs.2021.119431. View

12.

Vimalraj S, Miranda P, Ramyakrishna B, Selvamurugan N . Regulation of breast cancer and bone metastasis by microRNAs. Dis Markers. 2013; 35(5):369-87. PMC: 3809754. DOI: 10.1155/2013/451248. View

13.

Mansoori B, Najafi S, Mohammadi A, AsadollahSeraj H, Savadi P, Mansoori B . The synergy between miR-486-5p and tamoxifen causes profound cell death of tamoxifen-resistant breast cancer cells. Biomed Pharmacother. 2021; 141:111925. DOI: 10.1016/j.biopha.2021.111925. View

14.

Maimaitiming A, Wusiman A, Aimudula A, Kuerban X, Su P . MicroRNA-152 Inhibits Cell Proliferation, Migration, and Invasion in Breast Cancer. Oncol Res. 2019; 28(1):13-19. PMC: 7851537. DOI: 10.3727/096504019X15519249902838. View

15.

Imani S, Wu R, Fu J . MicroRNA-34 family in breast cancer: from research to therapeutic potential. J Cancer. 2018; 9(20):3765-3775. PMC: 6216011. DOI: 10.7150/jca.25576. View

16.

Chen Z, Shi H, Sun S, Xu H, Cao D, Luo J . MicroRNA-181b suppresses TAG via target IRS2 and regulating multiple genes in the Hippo pathway. Exp Cell Res. 2016; 348(1):66-74. DOI: 10.1016/j.yexcr.2016.09.004. View

17.

Avril-Sassen S, Goldstein L, Stingl J, Blenkiron C, Le Quesne J, Spiteri I . Characterisation of microRNA expression in post-natal mouse mammary gland development. BMC Genomics. 2009; 10:548. PMC: 2784809. DOI: 10.1186/1471-2164-10-548. View

18.

Cai Q, Yang H, Li Y, Zhu J . Dissecting the Roles of PDCD4 in Breast Cancer. Front Oncol. 2022; 12:855807. PMC: 9251513. DOI: 10.3389/fonc.2022.855807. View

19.

Long J, Ji Z, Jiang K, Wang Z, Meng G . miR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1. Biomed Res Int. 2015; 2015:373574. PMC: 4615858. DOI: 10.1155/2015/373574. View

20.

Bilkovski R, Schulte D, Oberhauser F, Gomolka M, Udelhoven M, Hettich M . Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes. J Biol Chem. 2009; 285(9):6170-8. PMC: 2825412. DOI: 10.1074/jbc.M109.054338. View