The Metastatic Process Through the Eyes of Epigenetic Regulation: A Promising Horizon for Cancer Therapy
Overview
Overview
Journal
Int J Mol Sci
Publisher
MDPI
Specialties
Biochemistry
Chemistry
Molecular Biology
Chemistry
Molecular Biology
Date
2022 Dec 23
PMID
36555088
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Genetic aberrations, including chromosomal rearrangements, loss or amplification of DNA, and point mutations, are major elements of cancer development [...].
References
1.
Kitz J, Lefebvre C, Carlos J, Lowes L, Allan A
. Reduced Expression in Prostate Cancer Cells Leads to an Aggressive Partial-EMT Phenotype Associated with Altered Global Methylation Patterns. Int J Mol Sci. 2021; 22(23).
PMC: 8657557.
DOI: 10.3390/ijms222312840.
View
2.
Morel D, Jeffery D, Aspeslagh S, Almouzni G, Postel-Vinay S
. Combining epigenetic drugs with other therapies for solid tumours - past lessons and future promise. Nat Rev Clin Oncol. 2019; 17(2):91-107.
DOI: 10.1038/s41571-019-0267-4.
View
3.
Shibue T, Weinberg R
. EMT, CSCs, and drug resistance: the mechanistic link and clinical implications. Nat Rev Clin Oncol. 2017; 14(10):611-629.
PMC: 5720366.
DOI: 10.1038/nrclinonc.2017.44.
View
4.
Reiter J, Makohon-Moore A, Gerold J, Heyde A, Attiyeh M, Kohutek Z
. Minimal functional driver gene heterogeneity among untreated metastases. Science. 2018; 361(6406):1033-1037.
PMC: 6329287.
DOI: 10.1126/science.aat7171.
View
5.
Ruscitto F, Roda N, Priami C, Migliaccio E, Pelicci P
. Beyond Genetics: Metastasis as an Adaptive Response in Breast Cancer. Int J Mol Sci. 2022; 23(11).
PMC: 9181003.
DOI: 10.3390/ijms23116271.
View