The Pitfall of Ganglioneuroblastoma-Nodular Diagnosis: Clinical and Imaging Considerations over a Rare Bifocal Sporadic Case

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2022 Dec 23

PMID 36553228

Authors

Claudio Montante

Francesco Fabozzi

Maria Felicia Villani

Maria Luisa DAndrea

Alessandra Stracuzzi

Gian Luigi Natali

Giada Del Baldo

Francesca Del Bufalo

Maria Carmen Garganese

Annalisa Serra

Paolo Toma

Rita Alaggio

Sabina Vennarini

Giovanna Stefania Colafati

Angela Mastronuzzi

Maria Antonietta De Ioris

Affiliations

Soon will be listed here.

Abstract

Neuroblastic tumors (NTs) represent the most common extracranial neoplasm occurring in childhood. Although ganglioneuroblastoma intermixed (GNBI) and ganglioneuroma (GN) are classified as very low-risk tumors, neuroblastoma (NB) and ganglioneuroblastoma-nodular (GNBN) may represent a serious risk to survival. Unfortunately, areas of GNBI and GNBN can coexist in the same mass, leading to incorrect risk staging when only biopsy is performed. Herein, we describe a case of multifocal NT (thoracic and abdominal localization) occurring in a 4-year-old male. Different histological subtypes, namely GNBI and GNBN, were revealed in the two lesions. We focus on the difficulties of proper diagnosis and risk stratification, underlining the usefulness of several diagnostic tools for appropriate management and therapeutic choices.

Citing Articles

A needle in the haystack: An unusual case presentation of ganglioneuroblastoma at a tertiary care center in Coastal Karnataka.

Radhakrishnan S, Rao R, Lashkari H, Kini H, Kini J, Kudurugundi V Clin Case Rep. 2023; 11(11):e8149.

PMID: 38028045 PMC: 10665580. DOI: 10.1002/ccr3.8149.

Computer-assisted rescue of the inferior mesenteric artery in a child with a giant ganglioneuroblastoma: A case report.

Xiu W, Liu J, Zhang J, Su N, Wang F, Hao X World J Gastrointest Surg. 2023; 15(5):984-991.

PMID: 37342847 PMC: 10277949. DOI: 10.4240/wjgs.v15.i5.984.

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