Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2022 Dec 23

PMID 36553112

Authors

Melinda-Ildiko Mitranovici

Diana Maria Chiorean

Maria Cezara Muresan

Corneliu-Florin Buicu

Raluca Moraru

Liviu Moraru

Titiana Cornelia Cotoi

Ovidiu Simion Cotoi

Havva Serap Toru

Adrian Apostol

Sabin Gligore Turdean

Claudiu Marginean

Ion Petre

Ioan Emilian Oala

Zsuzsanna Simon-Szabo

Viviana Ivan

Lucian Puscasiu

Affiliations

Soon will be listed here.

Abstract

Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well.

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