Modeling of Red Blood Cells in Capillary Flow Using Fluid-Structure Interaction and Gas Diffusion

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Dec 23

PMID 36552751

Authors

Ling An

Fenglong Ji

Yueming Yin

Yi Liu

Chichun Zhou

Affiliations

Soon will be listed here.

Abstract

Red blood cell (RBC) distribution, RBC shape, and flow rate have all been shown to have an effect on the pulmonary diffusing capacity. Through this study, a gas diffusion model and the immersed finite element method were used to simulate the gas diffusion into deformable RBCs running in capillaries. It has been discovered that when RBCs are deformed, the CO flux across the membrane becomes nonuniform, resulting in a reduced capacity for diffusion. Additionally, when compared to RBCs that were dispersed evenly, our simulation showed that clustered RBCs had a significantly lower diffusion capability.

References

Hsia C, JOHNSON Jr R, Shah D . Red cell distribution and the recruitment of pulmonary diffusing capacity. J Appl Physiol (1985). 1999; 86(5):1460-7. DOI: 10.1152/jappl.1999.86.5.1460. View

Tan J, Thomas A, Liu Y . Influence of Red Blood Cells on Nanoparticle Targeted Delivery in Microcirculation. Soft Matter. 2012; 8:1934-1946. PMC: 3286618. DOI: 10.1039/C2SM06391C. View

Frank A, Chuong C, Johnson R . A finite-element model of oxygen diffusion in the pulmonary capillaries. J Appl Physiol (1985). 1997; 82(6):2036-44. DOI: 10.1152/jappl.1997.82.6.2036. View

Krogh M . The diffusion of gases through the lungs of man. J Physiol. 1915; 49(4):271-300. PMC: 1420569. DOI: 10.1113/jphysiol.1915.sp001710. View

Liu W, Liu Y, Farrell D, Zhang L, Wang X, Fukui Y . Immersed finite element method and its applications to biological systems. Comput Methods Appl Mech Eng. 2011; 195(13-16):1722-1749. PMC: 2830735. DOI: 10.1016/j.cma.2005.05.049. View

D R Borland C, B Hughes J . Lung Diffusing Capacities (D ) for Nitric Oxide (NO) and Carbon Monoxide (CO): The Evolving Story. Compr Physiol. 2019; 10(1):73-97. DOI: 10.1002/cphy.c190001. View

Whiteley J, Gavaghan D, Hahn C . Mathematical modelling of pulmonary gas transport. J Math Biol. 2003; 47(1):79-99. DOI: 10.1007/s00285-003-0196-8. View

Wang S, Cho Y, Cheng X, Yang S, Liu Y, Liu Y . Integration of Hierarchical Micro-/Nanostructures in a Microfluidic Chip for Efficient and Selective Isolation of Rare Tumor Cells. Micromachines (Basel). 2019; 10(10). PMC: 6843196. DOI: 10.3390/mi10100698. View

Eggleton C, Popel A . Large deformation of red blood cell ghosts in a simple shear flow. Phys Fluids (1994). 2017; 10(8):1834-1845. PMC: 5438868. DOI: 10.1063/1.869703. View

10.

Evans E, Fung Y . Improved measurements of the erythrocyte geometry. Microvasc Res. 1972; 4(4):335-47. DOI: 10.1016/0026-2862(72)90069-6. View

11.

Presson Jr R, Graham J, Hanger C, Godbey P, Gebb S, Sidner R . Distribution of pulmonary capillary red blood cell transit times. J Appl Physiol (1985). 1995; 79(2):382-8. DOI: 10.1152/jappl.1995.79.2.382. View

12.

Liu Y, Chung J, Liu W, Ruoff R . Dielectrophoretic assembly of nanowires. J Phys Chem B. 2006; 110(29):14098-106. DOI: 10.1021/jp061367e. View

13.

Betticher D, Reinhart W, Geiser J . Effect of RBC shape and deformability on pulmonary O2 diffusing capacity and resistance to flow in rabbit lungs. J Appl Physiol (1985). 1995; 78(3):778-83. DOI: 10.1152/jappl.1995.78.3.778. View

14.

Pozrikidis C . Numerical simulation of the flow-induced deformation of red blood cells. Ann Biomed Eng. 2003; 31(10):1194-205. DOI: 10.1114/1.1617985. View

15.

Bates D, PEARCE J . The pulmonary diffusing capacity; a comparison of methods of measurement and a study of the effect of body position. J Physiol. 1956; 132(1):232-8. PMC: 1363554. DOI: 10.1113/jphysiol.1956.sp005517. View