Açai Berry Attenuates Cyclophosphamide-Induced Damage in Genitourinary Axis-Modulating Nrf-2/HO-1 Pathways

Overview

Journal Antioxidants (Basel)

Date 2022 Dec 23

PMID 36552563

Authors

Rosalba Siracusa

Ramona DAmico

Roberta Fusco

Daniela Impellizzeri

Alessio Filippo Peritore

Enrico Gugliandolo

Rosalia Crupi

Livia Interdonato

Marika Cordaro

Salvatore Cuzzocrea

Rosanna Di Paola

Affiliations

Soon will be listed here.

Abstract

Methods: CYP was administered intraperitoneally once during the experiment at a dose of 200 mg/kg body weight diluted in 10 mL/kg b.w. of water. Açai berry was administered orally at a dose of 500 mg/kg.

Results: The administration of açai berry was able to reduce inflammation, oxidative stress, lipid peroxidation, apoptosis, and histological changes in the bladder and testes after CYP injection.

Conclusions: Our findings show for the first time that açai berry modulates physiological antioxidant defenses to protect the bladder and testes against CYP-induced changes.

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