Protective Application of and Its Extracts in Animal Production

Overview

Journal Animals (Basel)

Date 2022 Dec 23

PMID 36552461

Authors

Lixue Wang

Huaqi Gao

Cui Sun

Lingxia Huang

Affiliations

Soon will be listed here.

Abstract

Different components of the mulberry tree (fruits, leaves, twigs, and roots) are rich in active compounds, and have been reported to possess potent beneficial properties, including antioxidative, anti-inflammatory, antimicrobial, anticancer, anti-allergenic, antihypertensive, and neuroprotective. The mulberry and its extracts can effectively improve the growth performance and fitness of animals. They not only possess the properties of being safe and purely natural, but also they are not prone to drug resistance. According to the literature, the supplemental level of the mulberry and its extracts in animal diets varies with different species, physiological status, age, and the purpose of the addition. It has been observed that the mulberry and its extracts enhanced the growth performance, the quality of animal products (meat, egg, and milk), the antioxidant and the anti-inflammatory responses of animals. Furthermore, the mulberry and its extracts have antibacterial properties and can effectively moderate the relative abundance of the microbial populations in the rumen and intestines, thus improving the immunity function of animals and reducing the enteric methane (CH) production in ruminants. Furthermore, the mulberry and its extracts have the potential to depurate tissues of heavy metals. Collectively, this review summarizes the nutrients, active compounds, and biological functions of mulberry tree products, as well as the application in livestock production with an aim to provide a reference for the utilization of the mulberry and its extracts in animal production.

Citing Articles

Dietary supplementation of mulberry leaf oligosaccharides improves the growth, glucose and lipid metabolism, immunity, and virus resistance in largemouth bass ().

Zhou D, Zhong W, Fu B, Li E, Hao L, Li Q Front Immunol. 2025; 16:1525992.

PMID: 39935475 PMC: 11811104. DOI: 10.3389/fimmu.2025.1525992.

Dietary Paper Mulberry Silage Supplementation Improves the Growth Performance, Carcass Characteristics, and Meat Quality of Yangzhou Goose.

Wang R, Wang X, Xiong Y, Cao J, Nussio L, Ni K Animals (Basel). 2024; 14(3).

PMID: 38338002 PMC: 10854908. DOI: 10.3390/ani14030359.

- Invited Review - Translational gut microbiome research for strategies to improve beef cattle production sustainability and meat quality.

Mizoguchi Y, Guan L Anim Biosci. 2024; 37(2):346-359.

PMID: 38186252 PMC: 10838664. DOI: 10.5713/ab.23.0387.

Effects of Mulberry Leaf Extract on the Liver Function of Juvenile Spotted Sea Bass ().

Zhou S, Lin H, Kong L, Ma J, Long Z, Qin H Aquac Nutr. 2023; 2023:2892463.

PMID: 37908498 PMC: 10615578. DOI: 10.1155/2023/2892463.

References

Li Q, Wang Y, Dai Y, Shen W, Liao S, Zou Y . 1-Deoxynojirimycin modulates glucose homeostasis by regulating the combination of IR-GlUT4 and ADIPO-GLUT4 pathways in 3T3-L1 adipocytes. Mol Biol Rep. 2019; 46(6):6277-6285. DOI: 10.1007/s11033-019-05069-y. View

Mengistu G, Assefa G, Tilahun S . Noug Seed () Cake Substituted with Dried Mulberry () and Mixed Leaves' Meal on Growth Performances of Bonga Sheep at Teppi, Ethiopia. J Nutr Metab. 2020; 2020:9308761. PMC: 7533002. DOI: 10.1155/2020/9308761. View

Srivastava S, Kapoor R, Thathola A, Srivastava R . Nutritional quality of leaves of some genotypes of mulberry (Morus alba). Int J Food Sci Nutr. 2006; 57(5-6):305-13. DOI: 10.1080/09637480600801837. View

Lv F, Wang X, Pang X, Liu G . Effects of supplementary feeding on the rumen morphology and bacterial diversity in lambs. PeerJ. 2020; 8:e9353. PMC: 7307561. DOI: 10.7717/peerj.9353. View

Wang Y, Shen Q, Zhong S, Chen Y, Yang Y . Comparison of Rumen Microbiota and Serum Biochemical Indices in White Cashmere Goats Fed Ensiled or Sun-Dried Mulberry Leaves. Microorganisms. 2020; 8(7). PMC: 7409109. DOI: 10.3390/microorganisms8070981. View

Klaunig J . Oxidative Stress and Cancer. Curr Pharm Des. 2019; 24(40):4771-4778. DOI: 10.2174/1381612825666190215121712. View

Akbulut M, Ozcan M . Comparison of mineral contents of mulberry (Morus spp.) fruits and their pekmez (boiled mulberry juice) samples. Int J Food Sci Nutr. 2008; 60(3):231-9. DOI: 10.1080/09637480701695609. View

Wang B, Luo H . Effects of mulberry leaf silage on antioxidant and immunomodulatory activity and rumen bacterial community of lambs. BMC Microbiol. 2021; 21(1):250. PMC: 8454139. DOI: 10.1186/s12866-021-02311-1. View

Fu Y, Zhang Q, Xu D, Xia H, Cai X, Wang B . Parasiticidal effects of Morus alba root bark extracts against Ichthyophthirius multifiliis infecting grass carp. Dis Aquat Organ. 2014; 108(2):129-36. DOI: 10.3354/dao02708. View

10.

Peng B, Zhu Q, Zhong Y, Xu S, Wang Z . Chlorogenic Acid Maintains Glucose Homeostasis through Modulating the Expression of SGLT-1, GLUT-2, and PLG in Different Intestinal Segments of Sprague-Dawley Rats Fed a High-Fat Diet. Biomed Environ Sci. 2016; 28(12):894-903. DOI: 10.3967/bes2015.123. View

11.

Liu Y, Li Y, Xiao Y, Peng Y, He J, Chen C . Mulberry leaf powder regulates antioxidative capacity and lipid metabolism in finishing pigs. Anim Nutr. 2021; 7(2):421-429. PMC: 8245823. DOI: 10.1016/j.aninu.2020.08.005. View

12.

Yan Y, Zhou X, Guo K, Zhou F, Yang H . Chlorogenic Acid Protects Against Indomethacin-Induced Inflammation and Mucosa Damage by Decreasing -Derived LPS. Front Immunol. 2020; 11:1125. PMC: 7283755. DOI: 10.3389/fimmu.2020.01125. View

13.

Jang A, Liu X, Shin M, Lee B, Lee S, Lee J . Antioxidative potential of raw breast meat from broiler chicks fed a dietary medicinal herb extract mix. Poult Sci. 2008; 87(11):2382-9. DOI: 10.3382/ps.2007-00506. View

14.

Chen G, Shui S, Chai M, Wang D, Su Y, Wu H . Effects of Paper Mulberry () Leaf Extract on Growth Performance and Fecal Microflora of Weaned Piglets. Biomed Res Int. 2020; 2020:6508494. PMC: 7700021. DOI: 10.1155/2020/6508494. View

15.

Fan L, Peng Y, Wu D, Hu J, Shi X, Yang G . Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig model. J Ethnopharmacol. 2019; 249:112416. DOI: 10.1016/j.jep.2019.112416. View

16.

Zhang S, Soltis D, Yang Y, Li D, Yi T . Multi-gene analysis provides a well-supported phylogeny of Rosales. Mol Phylogenet Evol. 2011; 60(1):21-8. DOI: 10.1016/j.ympev.2011.04.008. View

17.

Chen X, Sheng Z, Qiu S, Yang H, Jia J, Wang J . Purification, characterization and in vitro and in vivo immune enhancement of polysaccharides from mulberry leaves. PLoS One. 2019; 14(1):e0208611. PMC: 6314569. DOI: 10.1371/journal.pone.0208611. View

18.

Welte C . Revival of Archaeal Methane Microbiology. mSystems. 2018; 3(2). PMC: 5881026. DOI: 10.1128/mSystems.00181-17. View

19.

Parida I, Takasu S, Ito J, Ikeda R, Yamagishi K, Kimura T . Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue. Food Funct. 2020; 11(5):3926-3940. DOI: 10.1039/d0fo00271b. View

20.

Zeng J, Wan X, Liu T, Xiong Y, Xiang G, Peng Y . Chlorogenic acid ameliorates -induced pneumonia in immunosuppressed mice inhibiting the activation of NLRP3 inflammasomes. Food Funct. 2021; 12(19):9466-9475. DOI: 10.1039/d0fo03185b. View