Methionine Metabolism Is Down-Regulated in Heart of Long-Lived Mammals

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2022 Dec 23

PMID 36552330

Authors

Natalia Mota-Martorell

Mariona Jove

Rebeca Berdun

Elia Obis

Gustavo Barja

Reinald Pamplona

Affiliations

Soon will be listed here.

Abstract

Methionine constitutes a central hub of intracellular metabolic adaptations leading to an extended longevity (maximum lifespan). The present study follows a comparative approach analyzing methionine and related metabolite and amino acid profiles using an LC-MS/MS platform in the hearts of seven mammalian species with a longevity ranging from 3.8 to 57 years. Our findings demonstrate the existence of species-specific heart phenotypes associated with high longevity characterized by: (i) low concentration of methionine and its related sulphur-containing metabolites; (ii) low amino acid pool; and (iii) low choline concentration. Our results support the existence of heart metabotypes characterized by a down-regulation in long-lived species, supporting the idea that in longevity, less is more.

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