Gangliosides and Their Role in Multilineage Differentiation of Mesenchymal Stem Cells

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2022 Dec 23

PMID 36551867

Authors

Francesca Santilli

Jessica Fabrizi

Fanny Pulcini

Costantino Santacroce

Maurizio Sorice

Simona Delle Monache

Vincenzo Mattei

Affiliations

Soon will be listed here.

Abstract

Gangliosides (GGs) are a glycolipid class present on Mesenchymal Stem Cells (MSCs) surfaces with a critical appearance role in stem cell differentiation, even though their mechanistic role in signaling and differentiation remains largely unknown. This review aims to carry out a critical analysis of the predictive role of gangliosides as specific markers of the cellular state of undifferentiated and differentiated MSCs, towards the osteogenic, chondrogenic, neurogenic, and adipogenic lineage. For this reason, we analyzed the role of GGs during multilineage differentiation processes of several types of MSCs such as Umbilical Cord-derived MSCs (UC-MSCs), Bone Marrow-derived MSCs (BM-MSCs), Dental Pulp derived MSCs (DPSCs), and Adipose derived MSCs (ADSCs). Moreover, we examined the possible role of GGs as specific cell surface markers to identify or isolate specific stem cell isotypes and their potential use as additional markers for quality control of cell-based therapies.

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