Molecular Genetic Epidemiology of an Emerging Antimicrobial-Resistant Clone (ST307) Obtained from Clinical Isolates in Central Panama

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2022 Dec 23

PMID 36551474

Authors

Virginia Nunez-Samudio

Gumercindo Pimentel-Peralta

Mellissa Herrera

Maydelin Pecchio

Johana Quintero

Ivan Landires

Affiliations

Soon will be listed here.

Abstract

Materials And Methods: We conducted an epidemiological study in three reference hospitals in the central region of Panama, using isolates of involved in infections, and identifying their AMR profile, associated clinical risk factors, and molecular typing using a multilocus sequence typing (ST) scheme.

Results: Six STs were detected: 307 (55%), 152, 18, 29, 405, and 207. CTX-M-15- and TEM-type beta-lactamases were identified in 100% of ESBL-producing strains; substitutions in Ser83Ile and parC Ser80Ile were identified in all ST307s; and in ST152 gyrA Ser83Phe, Asp87Ala, and parC Ser80Ile, the gene was detected in all strains resistant to ciprofloxacin.

Conclusions: We present the first report on ST307 in three reference hospitals in the central region of Panama, which is a high-risk emerging clone and represents a public health alert for potential difficulties in managing infections in Panama, and which may extend to other Central American countries.

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