Studies Regarding the Antimicrobial Behavior of Clotrimazole and Limonene

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2022 Dec 23

PMID 36551473

Authors

Verginica Schroder

Nicoleta Radu

Petruta Calina Cornea

Oana Andreia Coman

Lucia Camelia Pirvu

Mohammed Shaymaa Omar Mohammed

Amalia Stefaniu

Lucia Pintilie

Marinela Bostan

Mihai Dan Caramihai

Viviana Roman

Affiliations

Soon will be listed here.

Abstract

The paper presents the results of the studies performed to establish the effect of the mixtures between limonene and clotrimazole against microbial pathogens involved in dermatological diseases, such as , , and . Preliminary data obtained from the studies performed in microplates revealed a possible synergism between the mixture of clotrimazole and limonene for . Studies performed "in silico" with programs such as CLC Drug Discovery Workbench and MOLEGRO Virtual Docker, gave favorable scores for docking each compound on a specific binding site for each microorganism. The tests performed for validation, with the clotrimazole (0.1%) and different sources of limonene (1.9% citrus essential oils), showed a synergistic effect on in the case of the mixtures between clotrimazole and the essential oils of or . The studies performed on MRSA showed a synergistic effect between clotrimazole and the essential oils obtained from , , or . In the case of , essential oils and clotrimazole used alone did not exhibit antimicrobial activities, but the mixtures between clotrimazole and the essential oils of or exhibited a synergistic antimicrobial effect.

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