Degradation Mechanism of AAA+ Proteases and Regulation of Metabolism

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2022 Dec 23

PMID 36551276

Authors

Weifeng Xu

Wenli Gao

Qingting Bu

Yongquan Li

Affiliations

Soon will be listed here.

Abstract

Hundreds of proteins work together in microorganisms to coordinate and control normal activity in cells. Their degradation is not only the last step in the cell's lifespan but also the starting point for its recycling. In recent years, protein degradation has been extensively studied in both eukaryotic and prokaryotic organisms. Understanding the degradation process is essential for revealing the complex regulatory network in microorganisms, as well as further artificial reconstructions and applications. This review will discuss several studies on protein quality-control family members Lon, FtsH, ClpP, the proteasome in and a few classical model organisms, mainly focusing on their structure, recognition mechanisms, and metabolic influences.

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