Association Between Arsenic Exposure and Inflammatory Cytokines and C-reaction Protein: A Systematic Review and Meta-analysis

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2022 Dec 23

PMID 36550845

Authors

Zheyu Zhang

Ruozheng Pi

Jieya Luo

Ji Liu

Aihua Zhang

Baofei Sun

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have reported controversial results on levels of inflammatory cytokines in patients with arsenic exposure. This study aims to evaluate the associations between arsenic exposure and inflammatory cytokines and C-reaction protein (CRP).

Methods: We searched the databases including PubMed, Embase, Web of Science, and China national knowledge infrastructure (CNKI) for studies reporting levels of cytokines and CRP in patients with arsenic exposure compared to the controls. The retrieval time was from January 2000 to September 2022.

Results: 13 observational studies involving 1665 arsenic exposed and 1091 unexposed individuals were included. Among these studies, 6 from China, 4 from India, 2 from Bangladesh and 1 from Turkey. Our result showed that interleukin (IL)-6, IL-8, and IL-12 levels were significantly higher in arsenic-exposed individuals compared to the control group, IL-2 level was significantly lower, and Tumor necrosis factor-α, Interferon-γ, CRP, and IL-10 levels were not changed. After sensitivity analyses, tumor necrosis factor-α and Interferon-γ levels were significantly higher in arsenic-exposed individuals compared to the control group. High heterogeneity was detected in most studies.

Conclusion: Many cytokines (such as IL-6, IL-8, and IL-12) have altered in individuals with arsenic exposure, this indicates arsenic exposure could trigger the cell-mediated inflammatory response. Regular examining immune function (such as inflammatory cytokines) in individuals with the risk of arsenic exposure is important to human health.

Citing Articles

Cross-sectional study on urinary metal concentrations in young adult residents of Emirate of Sharjah, United Arab Emirates.

Masarani A, Khaled R, Hussein B, Alhammadi H, Al-Ali S, Kinbaz Y PLoS One. 2024; 19(11):e0312964.

PMID: 39499712 PMC: 11537376. DOI: 10.1371/journal.pone.0312964.

Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors.

Fatema K, Haidar Z, Tanim M, Nath S, Sajib A Toxicol Res. 2024; 40(4):653-672.

PMID: 39345741 PMC: 11436564. DOI: 10.1007/s43188-024-00255-y.

Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental Impact Risk on Human Health Including Clinical Liver Injury.

Teschke R Int J Mol Sci. 2024; 25(12).

PMID: 38928368 PMC: 11203474. DOI: 10.3390/ijms25126662.

Associations of Urinary Total Arsenic and Arsenic Species and Periodontitis.

Yang H, Wang J, Chen Q, Wu Y, Wu Y, Deng Q Int Dent J. 2024; 74(4):713-721.

PMID: 38388241 PMC: 11287149. DOI: 10.1016/j.identj.2024.01.025.

References

Gao Y, Zhao Z, Yang L, Liu X, Xing X, Zhang H . Arsenic exposure assists ccm3 genetic polymorphism in elevating blood pressure. Oncotarget. 2018; 9(4):4915-4923. PMC: 5797022. DOI: 10.18632/oncotarget.23518. View

Oliveira E, Caixeta E, Santos V, Pereira B . Arsenic exposure from groundwater: environmental contamination, human health effects, and sustainable solutions. J Toxicol Environ Health B Crit Rev. 2021; 24(3):119-135. DOI: 10.1080/10937404.2021.1898504. View

Yan N, Xu G, Zhang C, Liu X, Li X, Sun L . Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen. Cell Biosci. 2020; 10:91. PMC: 7391604. DOI: 10.1186/s13578-020-00448-6. View

Xu Y, Zou Z, Liu Y, Wang Q, Sun B, Zeng Q . miR-191 is involved in renal dysfunction in arsenic-exposed populations by regulating inflammatory response caused by arsenic from burning arsenic-contaminated coal. Hum Exp Toxicol. 2019; 39(1):37-46. DOI: 10.1177/0960327119874423. View

Das N, Paul S, Chatterjee D, Banerjee N, Majumder N, Sarma N . Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India. BMC Public Health. 2012; 12:639. PMC: 3441389. DOI: 10.1186/1471-2458-12-639. View

Minatel B, Sage A, Anderson C, Hubaux R, Marshall E, Lam W . Environmental arsenic exposure: From genetic susceptibility to pathogenesis. Environ Int. 2017; 112:183-197. DOI: 10.1016/j.envint.2017.12.017. View

Naujokas M, Anderson B, Ahsan H, Aposhian H, Graziano J, Thompson C . The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem. Environ Health Perspect. 2013; 121(3):295-302. PMC: 3621177. DOI: 10.1289/ehp.1205875. View

Carlin D, Naujokas M, Bradham K, Cowden J, Heacock M, Henry H . Arsenic and Environmental Health: State of the Science and Future Research Opportunities. Environ Health Perspect. 2015; 124(7):890-9. PMC: 4937867. DOI: 10.1289/ehp.1510209. View

Ferrario D, Gribaldo L, Hartung T . Arsenic Exposure and Immunotoxicity: a Review Including the Possible Influence of Age and Sex. Curr Environ Health Rep. 2016; 3(1):1-12. DOI: 10.1007/s40572-016-0082-3. View

10.

Prasad P, Sinha D . Low-level arsenic causes chronic inflammation and suppresses expression of phagocytic receptors. Environ Sci Pollut Res Int. 2017; 24(12):11708-11721. DOI: 10.1007/s11356-017-8744-8. View

11.

Liu S, Sun Q, Wang F, Zhang L, Song Y, Xi S . Arsenic induced overexpression of inflammatory cytokines based on the human urothelial cell model in vitro and urinary secretion of individuals chronically exposed to arsenic. Chem Res Toxicol. 2014; 27(11):1934-42. DOI: 10.1021/tx5002783. View

12.

Zhao M, Sun Y, Jiang Y . Anti-VEGF therapy is not a magic bullet for diabetic retinopathy. Eye (Lond). 2019; 34(4):609-610. PMC: 7265293. DOI: 10.1038/s41433-019-0652-3. View

13.

Karim M, Rahman M, Islam K, Al Mamun A, Hossain S, Hossain E . Increases in oxidized low-density lipoprotein and other inflammatory and adhesion molecules with a concomitant decrease in high-density lipoprotein in the individuals exposed to arsenic in Bangladesh. Toxicol Sci. 2013; 135(1):17-25. DOI: 10.1093/toxsci/kft130. View

14.

Duan X, Gao S, Li J, Wu L, Zhang Y, Li W . Acute arsenic exposure induces inflammatory responses and CD4 T cell subpopulations differentiation in spleen and thymus with the involvement of MAPK, NF-kB, and Nrf2. Mol Immunol. 2016; 81:160-172. DOI: 10.1016/j.molimm.2016.12.005. View

15.

Tutkun L, Gunduzoz M, Turksoy V, Deniz S, Oztan O, Cetintepe S . Arsenic-induced inflammation in workers. Mol Biol Rep. 2019; 46(2):2371-2378. DOI: 10.1007/s11033-019-04694-x. View

16.

Zhao L, Yang S, Guo Y, Sun G, Li B . Chronic arsenic exposure in drinking water interferes with the balances of T lymphocyte subpopulations as well as stimulates the functions of dendritic cells in vivo. Int Immunopharmacol. 2019; 71:115-131. DOI: 10.1016/j.intimp.2019.03.022. View

17.

Suntararuks S, Worasuttayangkurn L, Akanimanee J, Suriyo T, Nookabkaew S, Srisamut N . Sodium arsenite exposure impairs B cell proliferation and enhances vascular inflammation in Plasmodium berghei mouse model. Environ Toxicol Pharmacol. 2018; 66:7-13. DOI: 10.1016/j.etap.2018.12.010. View

18.

Wu C, Huang Y, Chung C, Huang C, Pu Y, Shiue H . Polymorphism of inflammatory genes and arsenic methylation capacity are associated with urothelial carcinoma. Toxicol Appl Pharmacol. 2013; 272(1):30-6. DOI: 10.1016/j.taap.2013.05.019. View

19.

Kany S, Vollrath J, Relja B . Cytokines in Inflammatory Disease. Int J Mol Sci. 2019; 20(23). PMC: 6929211. DOI: 10.3390/ijms20236008. View

20.

Rahaman M, Rahman M, Mise N, Sikder M, Ichihara G, Uddin M . Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management. Environ Pollut. 2021; 289:117940. DOI: 10.1016/j.envpol.2021.117940. View