The Role and Application of Exosomes and Their Cargos in Reproductive Diseases: A Systematic Review

Overview

Journal Vet Sci

Publisher MDPI

Specialty Veterinary Medicine

Date 2022 Dec 22

PMID 36548867

Authors

Zhi Chen

Xiangguo Wang

Affiliations

Soon will be listed here.

Abstract

In recent years, the incidence of the reproductive diseases is increasing year-by-year, leading to abortion or fetal arrest, which seriously affects the reproductive health of human beings and the reproductive efficiency of animals. Exosomes are phospholipid bilayer vesicles that are widely distributed in living organisms and released by the cells of various organs and tissues. Exosomes contain proteins, RNA, lipids, and other components and are important carriers of information transfer between cells, which play a variety of physiological and pathological regulatory functions. More and more studies have found that exosomes and their connotations play an important role in the diagnosis, prognosis and treatment of diseases. A systematic review was conducted in this manuscript and then highlights our knowledge about the diagnostic and therapeutic applications of exosomes to reproductive diseases, such as polycystic ovary syndrome (PCOS), endometriosis, premature ovarian failure (POF), preeclampsia, polycystic, endometrial cancer, cervical cancer, ovarian cancer, and prostate gland cancer.

Citing Articles

Extracellular Vesicle-Derived Cord Blood Plasma and Photobiomodulation Therapy Down-Regulated Caspase 3, LC3 and Beclin 1 Markers in the PCOS Oocyte: An Study.

Sahraeian S, Abbaszadeh H, Taheripanah R, Edalatmanesh M J Lasers Med Sci. 2023; 14:e23.

PMID: 37583503 PMC: 10423959. DOI: 10.34172/jlms.2023.23.

References

Guo Y, Wang X, Wang K, He Y . Appraising the Value of Serum and Serum-Derived Exosomal LncRNA-EXOC7 as a Promising Biomarker in Cervical Cancer. Clin Lab. 2020; 66(7). DOI: 10.7754/Clin.Lab.2019.191203. View

Bao S, Hu T, Liu J, Su J, Sun J, Ming Y . Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancer. J Nanobiotechnology. 2021; 19(1):22. PMC: 7802300. DOI: 10.1186/s12951-020-00767-3. View

Miranda M, Nascimento H, Costa M, Costa N, Brito K, Lopes C . Increasing of blastocyst rate and gene expression in co-culture of bovine embryos with adult adipose tissue-derived mesenchymal stem cells. J Assist Reprod Genet. 2016; 33(10):1395-1403. PMC: 5065556. DOI: 10.1007/s10815-016-0779-0. View

Nazri H, Imran M, Fischer R, Heilig R, Manek S, Dragovic R . Characterization of exosomes in peritoneal fluid of endometriosis patients. Fertil Steril. 2020; 113(2):364-373.e2. PMC: 7057257. DOI: 10.1016/j.fertnstert.2019.09.032. View

Zheng M, Hou L, Ma Y, Zhou L, Wang F, Cheng B . Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors. Mol Cancer. 2019; 18(1):76. PMC: 6446401. DOI: 10.1186/s12943-019-0999-x. View

Luo X, Wei J, Yang F, Pang X, Shi F, Wei Y . Exosomal lncRNA HNF1A-AS1 affects cisplatin resistance in cervical cancer cells through regulating microRNA-34b/TUFT1 axis. Cancer Cell Int. 2019; 19:323. PMC: 6889431. DOI: 10.1186/s12935-019-1042-4. View

Karedath T, Ahmed I, Al Ameri W, Al-Dasim F, Andrews S, Samuel S . Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes. BMC Cancer. 2019; 19(1):565. PMC: 6558796. DOI: 10.1186/s12885-019-5723-0. View

Li T, Sun X, Chen L . Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker. J Cell Biochem. 2019; 121(3):2118-2126. DOI: 10.1002/jcb.28239. View

Sun H, Li D, Yuan M, Li Q, Li N, Wang G . Eutopic stromal cells of endometriosis promote neuroangiogenesis via exosome pathway†. Biol Reprod. 2018; 100(3):649-659. DOI: 10.1093/biolre/ioy212. View

10.

Zhang Y, Liu Y, Liu H, Tang W . Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci. 2019; 9:19. PMC: 6377728. DOI: 10.1186/s13578-019-0282-2. View

11.

Huang B, Lu J, Ding C, Zou Q, Wang W, Li H . Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD. Stem Cell Res Ther. 2018; 9(1):216. PMC: 6085638. DOI: 10.1186/s13287-018-0953-7. View

12.

Zhu Z, Zhang Y, Zhang Y, Zhang H, Liu W, Zhang N . Exosomes derived from human umbilical cord mesenchymal stem cells accelerate growth of VK2 vaginal epithelial cells through MicroRNAs in vitro. Hum Reprod. 2018; 34(2):248-260. DOI: 10.1093/humrep/dey344. View

13.

Lopatina T, Bruno S, Tetta C, Kalinina N, Porta M, Camussi G . Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential. Cell Commun Signal. 2014; 12:26. PMC: 4022079. DOI: 10.1186/1478-811X-12-26. View

14.

Xu Y, Luo F, Liu Y, Shi L, Lu X, Xu W . Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis. Arch Toxicol. 2014; 89(7):1071-82. DOI: 10.1007/s00204-014-1291-x. View

15.

Henne W, Buchkovich N, Emr S . The ESCRT pathway. Dev Cell. 2011; 21(1):77-91. DOI: 10.1016/j.devcel.2011.05.015. View

16.

Wani S, Kaul D, Mavuduru R, Kakkar N, Bhatia A . Urinary-exosomal miR-2909: A novel pathognomonic trait of prostate cancer severity. J Biotechnol. 2017; 259:135-139. DOI: 10.1016/j.jbiotec.2017.07.029. View

17.

Bai Y, Han Y, Yan X, Ren J, Zeng Q, Li X . Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury. Biochem Biophys Res Commun. 2018; 500(2):310-317. DOI: 10.1016/j.bbrc.2018.04.065. View

18.

Herrero C, de la Fuente A, Casas-Arozamena C, Sebastian V, Prieto M, Arruebo M . Extracellular Vesicles-Based Biomarkers Represent a Promising Liquid Biopsy in Endometrial Cancer. Cancers (Basel). 2019; 11(12). PMC: 6966595. DOI: 10.3390/cancers11122000. View

19.

Hu Q, Su H, Li J, Lyon C, Tang W, Wan M . Clinical applications of exosome membrane proteins. Precis Clin Med. 2020; 3(1):54-66. PMC: 7099650. DOI: 10.1093/pcmedi/pbaa007. View

20.

Huang Q, Gong M, Tan T, Lin Y, Bao Y, Fan C . Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP. Nanoscale Res Lett. 2021; 16(1):27. PMC: 7876216. DOI: 10.1186/s11671-021-03475-5. View