Crystal Arthropathies and Osteoarthritis-where is the Link?

Overview

Journal Skeletal Radiol

Specialties Orthopedics
Radiology

Date 2022 Dec 20

PMID 36538066

Authors

Mohamed Jarraya

Frank Roemer

C Kent Kwoh

Ali Guermazi

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is one of the leading causes of disability worldwide. As our understanding of OA progressively has moved from a purely mechanical "wear and tear" concept toward a complex multi-tissue condition in which inflammation plays a central role, the possible role of crystal-induced inflammation in OA incidence and progression may be relevant. In addition to gout, which affects 4% of the US population, basic calcium phosphate and calcium pyrophosphate deposition both may induce joint inflammation and may play a role in pain in OA. This narrative review article discusses the possible mechanisms underlying the associations between crystal-induced arthropathies and OA, and the important implications of these for clinical practice and future research.

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References

Murphy L, Schwartz T, Helmick C, Renner J, Tudor G, Koch G . Lifetime risk of symptomatic knee osteoarthritis. Arthritis Rheum. 2008; 59(9):1207-13. PMC: 4516049. DOI: 10.1002/art.24021. View

Ma V, Chan L, Carruthers K . Incidence, prevalence, costs, and impact on disability of common conditions requiring rehabilitation in the United States: stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, osteoarthritis, rheumatoid arthritis, limb loss, and.... Arch Phys Med Rehabil. 2014; 95(5):986-995.e1. PMC: 4180670. DOI: 10.1016/j.apmr.2013.10.032. View

Abramson S, Attur M, Yazici Y . Prospects for disease modification in osteoarthritis. Nat Clin Pract Rheumatol. 2006; 2(6):304-12. DOI: 10.1038/ncprheum0193. View

Roemer F, Guermazi A, Felson D, Niu J, Nevitt M, Crema M . Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study. Ann Rheum Dis. 2011; 70(10):1804-9. PMC: 3496084. DOI: 10.1136/ard.2011.150243. View

Zhang Y, Nevitt M, Niu J, Lewis C, Torner J, Guermazi A . Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging. Arthritis Rheum. 2011; 63(3):691-9. PMC: 3056156. DOI: 10.1002/art.30148. View

Krasnokutsky S, Belitskaya-Levy I, Bencardino J, Samuels J, Attur M, Regatte R . Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis. Arthritis Rheum. 2011; 63(10):2983-91. PMC: 3183134. DOI: 10.1002/art.30471. View

Neogi T, Krasnokutsky S, Pillinger M . Urate and osteoarthritis: Evidence for a reciprocal relationship. Joint Bone Spine. 2018; 86(5):576-582. PMC: 6531371. DOI: 10.1016/j.jbspin.2018.11.002. View

Conway R, McCarthy G . Calcium-Containing Crystals and Osteoarthritis: an Unhealthy Alliance. Curr Rheumatol Rep. 2018; 20(3):13. DOI: 10.1007/s11926-018-0721-9. View

Zell M, Aung T, Kaldas M, Rosenthal A, Bai B, Liu T . Calcium pyrophosphate crystal size and characteristics. Osteoarthr Cartil Open. 2021; 3(1). PMC: 8356773. DOI: 10.1016/j.ocarto.2020.100133. View

10.

McCarthy G, Dunne A . Calcium crystal deposition diseases - beyond gout. Nat Rev Rheumatol. 2018; 14(10):592-602. DOI: 10.1038/s41584-018-0078-5. View

11.

Rosenthal A, Ryan L . Nonpharmacologic and pharmacologic management of CPP crystal arthritis and BCP arthropathy and periarticular syndromes. Rheum Dis Clin North Am. 2014; 40(2):343-56. PMC: 6240445. DOI: 10.1016/j.rdc.2014.01.010. View

12.

Rosenthal A . Basic calcium phosphate crystal-associated musculoskeletal syndromes: an update. Curr Opin Rheumatol. 2017; 30(2):168-172. PMC: 6241512. DOI: 10.1097/BOR.0000000000000477. View

13.

McCarty D, Halverson P, Carrera G, Brewer B, Kozin F . "Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. I. Clinical aspects. Arthritis Rheum. 1981; 24(3):464-73. DOI: 10.1002/art.1780240303. View

14.

Jones A, Chuck A, Arie E, Green D, Doherty M . Diseases associated with calcium pyrophosphate deposition disease. Semin Arthritis Rheum. 1992; 22(3):188-202. DOI: 10.1016/0049-0172(92)90019-a. View

15.

Ramonda R, Musacchio E, Perissinotto E, Sartori L, Punzi L, Corti M . Prevalence of chondrocalcinosis in Italian subjects from northeastern Italy. The Pro.V.A. (PROgetto Veneto Anziani) study. Clin Exp Rheumatol. 2010; 27(6):981-4. View

16.

Felson D, Anderson J, Naimark A, Kannel W, Meenan R . The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham Study. J Rheumatol. 1989; 16(9):1241-5. View

17.

Derfus B, Kurian J, Butler J, Daft L, Carrera G, Ryan L . The high prevalence of pathologic calcium crystals in pre-operative knees. J Rheumatol. 2002; 29(3):570-4. View

18.

Fuerst M, Bertrand J, Lammers L, Dreier R, Echtermeyer F, Nitschke Y . Calcification of articular cartilage in human osteoarthritis. Arthritis Rheum. 2009; 60(9):2694-703. DOI: 10.1002/art.24774. View

19.

Meyer F, Dittmann A, Kornak U, Herbster M, Pap T, Lohmann C . Chondrocytes From Osteoarthritic and Chondrocalcinosis Cartilage Represent Different Phenotypes. Front Cell Dev Biol. 2021; 9:622287. PMC: 8107373. DOI: 10.3389/fcell.2021.622287. View

20.

Dieppe P, Swan A . Identification of crystals in synovial fluid. Ann Rheum Dis. 1999; 58(5):261-3. PMC: 1752883. DOI: 10.1136/ard.58.5.261. View