Characterization of Fecal Microbiomes of Osteoporotic Patients in Korea

Overview

Journal Pol J Microbiol

Specialty Microbiology

Date 2022 Dec 20

PMID 36537058

Authors

Asad Ul-Haq

Hoonhee Seo

Sujin Jo

HyunA Park

Sukyung Kim

Youngkyoung Lee

Saebim Lee

Je Hoon Jeong

Ho-Yeon Song

Affiliations

Soon will be listed here.

Abstract

An imbalanced gut microbiome has been linked to a higher risk of many bone-related diseases. The objective of this study was to discover biomarkers of osteoporosis (OP). So, we collected 76 stool samples (60 human controls and 16 OP patients), extracted DNA, and performed 16S ribosomal ribonucleic acid (rRNA) gene-based amplicon sequencing. Among the taxa with an average taxonomic composition greater than 1%, only the genus showed a significant difference between the two groups. The Linear Discriminant Effect Size analysis and qPCR experiments indicated the genus as a potential biomarker of OP. Moreover, a total of 11 metabolic pathways varied between the two groups. Our study concludes that the genus is potentially crucial for diagnosing and treating osteoporosis. The findings of this study might help researchers better understand OP from a microbiome perspective. This research might develop more effective diagnostic and treatment methods for OP in the future.

Citing Articles

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